The objective of this study was to determine the reliability of omeprazole as a marker for
CYP2C19 activity in Chinese subjects. In 27 healthy male Chinese subjects, the CYP2C19 …

Background Our objective was to study omeprazole as a single‐dose oral probe in the
determination of CYP2C19 phenotype in black subjects and to determine the correlation …

Omeprazole (20 mg orally) was given to 103 healthy Korean subjects and blood was taken 3
h alter administration. The plasma concentration ratio of omeprazole and …

Aims To evaluate the reliability of the omeprazole hydroxylation index as a marker for
polymorphic CYP2C19 activity in a Japanese population of healthy young subjects (n= 78) …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• The only existing study of CYP2C19*
17‐associated alterations in drug pharmacokinetics was retrospective and compared probe …

SUMMARY 1 CYP2C19 is a polymorphism of cytochrome P450, which is responsible for the
metabolism of many drugs. The genetic polymorphism shows interethnic variation and it has …

We present a new simple and reliable HPLC method for measuring omeprazole and its two
main metabolites in plasma. This can be used for studying CYP2C19 and CYP3A4 genetic …

Objectives: Omeprazole is metabolized mainly by CYP2C19 which has two major mutations
(CYP2C19* 2 in exon5 and CYP2C19* 3 in exon4) associated with the poor metabolizer …

Background: To investigate whether the pharmacodynamics and pharmacokinetics of
omeprazole (OPZ) are dependent of the CYP2C19 genotype status in Chinese people …

Omeprazole has been used as a drug probe for CYP2C19, but no systematic data are
available for Mexican populations. The aim of this study was to evaluate the phenotype …