The hallmarks of cancer comprise six biological capabilities acquired during the multistep
development of human tumors. The hallmarks constitute an organizing principle for …

The hallmarks of cancer described by Hanahan and Weinberg have proved seminal in our
understanding of cancer's common traits and in rational drug design. Not free of critique and …

The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity
of cancer phenotypes and genotypes into a provisional set of underlying principles. As …

Compiling significant advances from more than a decade of research, this text presents
breakthroughs in the prevention, treatment, and control of cancer-exploring the origin …

An enigma for cancer medicine lies in its complexity and variability, at all levels of
consideration. The hallmarks of cancer constitute an organizing principle that provides a …

Building on years of basic scientific discovery, recent advances in the fields of cancer
genetics and medicinal chemistry are now converging to revolutionize the treatment of …

It is a time of great promise and expectation for the applications of knowledge about
mechanisms of cancer toward more effective and enduring therapies for human disease …

In 2000, Hanahan and Weinberg [1] proposed that the remarkable diversity of neoplastic
diseases and of their underlying molecular mechanisms could be rationalized into six …

Lest we forget, within every higher organism, there are literally billions of cells with identical
genetic information that serve as constituents of the different tissues and organs. Given that …

Diagnosis and treatment of disease demand a sound understanding of the underlying
mechanisms, determining any Achilles' heel that can be targeted in effective therapies …