Purpose Over the past few years, more and more new selective molecules directed against
specific cellular targets have become available for cancer therapy, leading to impressive …

Tumor angiogenesis is recognized as a major therapeutic target in the fight against cancer.
The key involvement of angiogenesis in tumor growth and metastasis has started to redefine …

Abstract 'Metronomic chemotherapy'represents a novel anti-angiogenic strategy whereby
low-dose chemotherapy is utilized in a continuous fashion in order to target tumor …

The administration of chemotherapy at reduced doses given at regular, frequent time
intervals, termed 'metronomic'chemotherapy, presents an alternative to standard maximal …

Metronomic chemotherapy, continuous and dose‐dense administration of chemotherapeutic
drugs with lowered doses, is being evaluated for substituting, augmenting, or appending …

The introduction of the “maximum tolerated dose” in usual treatment protocols (and its
concomitant overt toxicity) made necessary the imposition of rest periods between cycles of …

Conventional cytotoxic anticancer chemotherapeutic drugs were developed with the intent of
treating cancer by direct killing or inhibition of growth of cycling tumour cells. Recently …

Metronomic chemotherapy is a low dosing treatment strategy that attracts growing scientific
and clinical interest. It refers to dense and uninterrupted administration of low doses of …

Over the last decade, metronomic chemotherapy has been increasingly considered as an
attractive strategy for treating cancer in a variety of settings. Beside pharmaco-economic …

In addition to proliferating cancer cells and various types of normal cells, such as those of
the bone marrow, conventional cytotoxic chemotherapeutics affect the endothelium of the …