The biogenesis and precise control of RNA m6A methylation

H Huang, H Weng, J Chen - Trends in Genetics, 2020 - cell.com
N 6-Methyladenosine (m 6 A) is the most prevalent internal RNA modification in mRNA, and
has been found to be highly conserved and hard-coded in mammals and other eukaryotic …

RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation

Y Yue, J Liu, C He - Genes & development, 2015 - genesdev.cshlp.org
N 6-methyladenosine (m6A) is the most prevalent and internal modification that occurs in the
messenger RNAs (mRNA) of most eukaryotes, although its functional relevance remained a …

The dynamic epitranscriptome: N6-methyladenosine and gene expression control

KD Meyer, SR Jaffrey - Nature reviews Molecular cell biology, 2014 - nature.com
Abstract N 6-methyladenosine (m6A) is a modified base that has long been known to be
present in non-coding RNAs, ribosomal RNA, polyadenylated RNA and at least one …

N6-methyladenosine modifications: interactions with novel RNA-binding proteins and roles in signal transduction

J Chen, X Fang, P Zhong, Z Song, X Hu - RNA biology, 2019 - Taylor & Francis
ABSTRACT RNA epigenetics has received a great deal of attention in recent years, and the
reversible N6-methyladenosine (m6A) modification on messenger RNAs (mRNAs) has …

N6-methyladenosine–encoded epitranscriptomics

N Liu, T Pan - Nature structural & molecular biology, 2016 - nature.com
Abstract N 6-methyladenosine (m 6 A) is the most abundant internal modification in
eukaryotic mRNA. Recent discoveries of the locations, functions and mechanisms of m 6 A …

m6A RNA methylation: from mechanisms to therapeutic potential

PC He, C He - The EMBO journal, 2021 - embopress.org
RNA carries a diverse array of chemical modifications that play important roles in the
regulation of gene expression. N 6‐methyladenosine (m6A), installed onto mRNA by the …

N6-methyladenosine-mediated gene regulation and therapeutic implications

Y Liu, D Yang, T Liu, J Chen, J Yu, P Yi - Trends in molecular medicine, 2023 - cell.com
Abstract N6-methyladenosine (m 6 A) RNA methylation is the most abundant form of mRNA
modification in eukaryotes and is at the front line of biological and biomedical research. This …

Biological roles of adenine methylation in RNA

K Boulias, EL Greer - Nature Reviews Genetics, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A) is one of the most abundant modifications of the
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …

N6‐methyladenosine (m6A) RNA modification in human cancer

FC Huo, ZM Zhu, DS Pei - Cell proliferation, 2020 - Wiley Online Library
Abstract N6‐methyladenosine (m6A) RNA modification, first discovered in 1974, is the most
prevalent, abundant and penetrating messenger RNA (mRNA) modification in eukaryotes …

RNA m6A modification in cancers: molecular mechanisms and potential clinical applications

C Gu, X Shi, C Dai, F Shen, G Rocco, J Chen, Z Huang… - The innovation, 2020 - cell.com
N 6-Methyladenosine (m 6 A) RNA modification brings a new dawn for RNA modification
researches in recent years. This posttranscriptional RNA modification is dynamic and …