Chromatin modification is an important epigenetic mechanism underlying neuroplasticity.
Histone methylation and acetylation have both been shown to modulate gene expression …

Cell lineage specification is accomplished by a concerted action of chromatin remodeling
and tissue-specific transcription factors. However, the mechanisms that induce and maintain …

Arc is an immediate-early gene whose genetic ablation selectively abrogates long-term
memory, indicating a critical role in memory consolidation. Although Arc protein is found at …

Histone acetylation of chromatin promotes dynamic transcriptional responses in neurons
that influence neuroplasticity critical for cognitive ability. It has been demonstrated that Tip60 …

Highlights•Histone modifications are highly dynamic in the brain and drive changes in many
behaviors including learning and memory.•Chromatin-associated proteins that interact with …

The generation of individual neurons (neurogenesis) during cortical development occurs in
discrete steps that are subtly regulated and orchestrated to ensure normal histogenesis and …

Epigenetic dysregulation is a common mechanism shared by molecularly and clinically
heterogenous neurodegenerative diseases (NDs). Histone acetylation homeostasis …

While epigenetic modifications have emerged as attractive substrates to integrate
environmental changes into the determination of cell identity and function, specific signals …

Aberrant histone acetylation contributes to age-dependent cognitive decline and
neurodegenerative diseases. We analyze the function of lysine acetyltransferase …

In recent years spectacular advances in the field of epigenetics have taken place. Multiple
lines of evidence that connect epigenetic regulation to brain functions have been …