Angiotensin-converting enzyme inhibition prevents arterial nuclear factor-κB activation, monocyte chemoattractant protein-1 expression, and macrophage infiltration in …

M Hernandez-Presa, C Bustos, M Ortego, J Tunon… - Circulation, 1997 - Am Heart Assoc
Background The migration of monocytes into the vessel wall is a critical event leading to the
development of atherosclerosis. Monocyte chemoattractant protein-1 (MCP-1) is the main …

Angiotensin II and tumor necrosis factor-α synergistically promote monocyte chemoattractant protein-1 expression: roles of NF-κB, p38, and reactive oxygen species

M Takahashi, E Suzuki, R Takeda… - American Journal …, 2008 - journals.physiology.org
We examined whether ANG II and TNF-α cooperatively induce vascular inflammation using
the expression of monocyte chemoattractant protein (MCP)-1 as a marker of vascular …

Monocyte chemoattractant protein-1 is an essential inflammatory mediator in angiotensin II-induced progression of established atherosclerosis in …

W Ni, S Kitamoto, M Ishibashi, M Usui… - … , and vascular biology, 2004 - Am Heart Assoc
Objective—Chronic inflammatory processes might be involved in the progression and
destabilization of atherosclerotic plaques. Therefore, identification of the mechanism …

ACE inhibitor quinapril reduces the arterial expression of NF-κB-dependent proinflammatory factors but not of collagen I in a rabbit model of atherosclerosis

MA Hernández-Presa, C Bustos, M Ortego… - The American journal of …, 1998 - Elsevier
Increasing evidence supports an association between inflammation and plaque rupture.
Macrophages and vascular smooth muscle cells are a source of cytokines and growth …

Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-κB activation induced by intracellular oxidative stress

ME Pueyo, W Gonzalez, A Nicoletti… - … , and vascular biology, 2000 - Am Heart Assoc
The recruitment of monocytes via the endothelial expression of vascular cell adhesion
molecule-1 (VCAM-1) is a key step in the formation of the initial lesion in atherosclerosis …

ACE inhibition lowers angiotensin II-induced chemokine expression by reduction of NF-κB activity and AT1 receptor expression

A Schmeisser, O Soehnlein, T Illmer, HM Lorenz… - Biochemical and …, 2004 - Elsevier
OBJECTIVE: Angiotensin converting enzyme (ACE) inhibitors significantly improve survival
in patients with atherosclerosis. Although ACE inhibitors reduce local angiotensin II (AngII) …

Angiotensin II induces monocyte chemoattractant protein-1 gene expression in rat vascular smooth muscle cells

XL Chen, PE Tummala, MT Olbrych… - Circulation …, 1998 - Am Heart Assoc
Monocyte infiltration into the vessel wall, a key initial step in the process of atherosclerosis,
is mediated in part by monocyte chemoattractant protein-1 (MCP-1). Hypertension …

Nitric oxide protects against leukocyte-endothelium interactions in the early stages of hypercholesterolemia

TW Gauthier, R Scalia, T Murohara, J Guo… - … , and vascular biology, 1995 - Am Heart Assoc
We studied the effects of CAS1609, a nitric oxide donor, on leukocyte-endothelial
interactions during the early stages of hypercholesterolemia in rat mesenteric …

Role of monocyte chemoattractant protein-1 in cardiovascular remodeling induced by chronic blockade of nitric oxide synthesis

M Koyanagi, K Egashira, S Kitamoto, W Ni… - Circulation, 2000 - Am Heart Assoc
Background—Chronic inhibition of endothelial nitric oxide (NO) synthesis by the
administration of N ω-nitro-l-arginine methyl ester (L-NAME) to rats induces early vascular …

Modulation of C-reactive protein–mediated monocyte chemoattractant protein-1 induction in human endothelial cells by anti-atherosclerosis drugs

V Pasceri, J Chang, JT Willerson, ETH Yeh - Circulation, 2001 - Am Heart Assoc
Background—C-reactive protein (CRP) induces adhesion molecule expression by
endothelial cells. However, the effects of CRP on chemokine expression by endothelial cells …