[HTML][HTML] A lung-selective delivery of mRNA encoding broadly neutralizing antibody against SARS-CoV-2 infection

W Tai, K Yang, Y Liu, R Li, S Feng, B Chai… - Nature …, 2023 - nature.com
The respiratory system, especially the lung, is the key site of pathological injury induced by
SARS-CoV-2 infection. Given the low feasibility of targeted delivery of antibodies into the …

[HTML][HTML] Intranasal delivery of replicating mRNA encoding neutralizing antibody against SARS-CoV-2 infection in mice

JQ Li, ZR Zhang, HQ Zhang, YN Zhang… - … and Targeted Therapy, 2021 - nature.com
The lung is the prophylaxis target against SARS-CoV-2 infection, and neutralizing
antibodies are a leading class of biological products against various infectious viral …

[HTML][HTML] Nasal delivery of broadly neutralizing antibodies protects mice from lethal challenge with SARS-CoV-2 delta and omicron variants

J Lu, Q Yin, R Pei, Q Zhang, Y Qu, Y Pan, L Sun, D Gao… - Virologica Sinica, 2022 - Elsevier
Multiple new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
have constantly emerged, as the delta and omicron variants, which have developed …

[HTML][HTML] Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA. 5 Omicron variant in mice

SM Scheaffer, D Lee, B Whitener, B Ying, K Wu… - Nature medicine, 2023 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
in the Omicron lineage has resulted in diminished Coronavirus Disease 2019 (COVID-19) …

[HTML][HTML] Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on spike and provides antiviral protection through inhalation-based …

P Hermet, B Delache, C Herate, E Wolf, G Kivi… - PLoS …, 2023 - journals.plos.org
The COVID-19 pandemic represents a global challenge that has impacted and is expected
to continue to impact the lives and health of people across the world for the foreseeable …

[HTML][HTML] A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2

Q Huang, K Ji, S Tian, F Wang, B Huang, Z Tong… - Nature …, 2021 - nature.com
The rapid expansion of the COVID-19 pandemic has made the development of a SARS-CoV-
2 vaccine a global health and economic priority. Taking advantage of versatility and rapid …

[HTML][HTML] SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

KS Corbett, DK Edwards, SR Leist, OM Abiona… - Nature, 2020 - nature.com
A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to
control the coronavirus disease 2019 (COVID-19) global pandemic. Structural studies have …

[HTML][HTML] mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

Z Wang, F Schmidt, Y Weisblum, F Muecksch… - Nature, 2021 - nature.com
Here we report on the antibody and memory B cell responses of a cohort of 20 volunteers
who received the Moderna (mRNA-1273) or Pfizer–BioNTech (BNT162b2) vaccine against …

[HTML][HTML] Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

C Li, W Zhan, Z Yang, C Tu, G Hu, X Zhang, W Song… - Cell, 2022 - cell.com
The effectiveness of SARS-CoV-2 vaccines and therapeutic antibodies have been limited by
the continuous emergence of viral variants and by the restricted diffusion of antibodies from …

[HTML][HTML] Therapeutic activity of an inhaled potent SARS-CoV-2 neutralizing human monoclonal antibody in hamsters

MS Piepenbrink, JG Park, FS Oladunni… - Cell Reports …, 2021 - cell.com
SARS-CoV-2 infection results in viral burden in the respiratory tract, enabling transmission
and leading to substantial lung pathology. The 1212C2 fully human monoclonal antibody …