Fusion peptides (FPs) in spike proteins are key players mediating early events in cell-to-cell
fusion, vital for intercellular viral spread. A proline residue located at the central FP region …

Mouse hepatitis virus (MHV; murine coronavirus) causes meningoencephalitis, myelitis, and
optic neuritis followed by axonal loss and demyelination. This murine virus is used as a …

The spike (S) glycoprotein of mouse hepatitis virus (MHV) plays a major role in the viral
pathogenesis. It is often processed into the N-terminal S1 and the C-terminal S2 subunits …

The spike glycoprotein of mouse hepatitis virus strain A59 mediates the early events leading
to infection of cells, including fusion of the viral and cellular membranes. The spike is a type I …

The prototype JHM strain of murine hepatitis virus (MHV) is an enveloped, RNA-containing
coronavirus that has been selected in vivo for extreme neurovirulence. This virus encodes …

The cleavage and fusion properties of recombinant murine hepatitis viruses (MHV) were
examined to assess the role of the cleavage signal in determining the extent of S protein …

Targeted recombination was carried out to select mouse hepatitis viruses (MHVs) in a
defined genetic background, containing an MHV-JHM spike gene encoding either three …

The spike (S) protein of coronavirus, mouse hepatitis virus (MHV), mediates attachment and
fusion during viral entry and cell-to-cell fusion later in infection. By analogy with other viral …

The spike (S) glycoprotein of mouse hepatitis virus (MHV) is a major determinant of
neurovirulence. Using targeted recombination we previously demonstrated that the S gene …

Demyelination is the pathologic hallmark of the human immune-mediated neurologic
disease multiple sclerosis, which may be triggered or exacerbated by viral infections …