Inorganic arsenic (iAs) exposure has been associated with the increased risk of various
forms of cancer and of non-cancerous diseases. Metabolic conversions of iAs that yield …

The relationship of exposure dose and tissue concentration of parent chemical and
metabolites is a critical issue in cases where toxicity may be mediated by a metabolite or by …

Chronic exposure to inorganic arsenic (iAs) has been associated with increased risk of
various forms of cancer and of noncancerous diseases. Metabolic conversions of iAs that …

Abstract Arsenic (+ 3 oxidation state) methyltransferase (As3mt) catalyzes methylation of
inorganic arsenic (iAs) producing a number of methylated arsenic metabolites. Although …

Arsenite (AsIII) is eliminated via excretion and methylation. Monomethylarsonous acid
(MMAsIII) is a super toxic metabolite of AsIII, while dimethylarsinic acid produced in the next …

The toxic metalloid inorganic arsenic (iAs) is widely distributed in the environment. Chronic
exposure to iAs from environmental sources has been linked to a variety of human diseases …

Recent studies have suggested that polymorphisms in the methylation of inorganic arsenic
(iAs) exist in animals and humans. Methylation of iAs is an important step in the elimination …

Biomethylation is the major metabolic pathway for inorganic arsenic (iAs) in humans. In this
pathway, iAs is metabolized to methylated arsenicals, including methylarsenic (MAs) and …

Inorganic arsenic is enzymatically methylated; hence, its ingestion results in exposure to the
parent compound and various methylated arsenicals. Both experimental and …

It is likely that at least some of the toxic and carcinogenic effects associated with exposure to
inorganic arsenic are, in fact, due to actions of its methylated metabolites. Here, we provide …