Mice lacking CD4 and/or CD8 gene expression, generated by embryonic stem-cell
technology, were used to study the role of CD4+ and CD8+ cells in the resistance to the …

The role of CD4+ and CD8+ T cells in the surveillance of Trypanosoma cruzi or
Trypanosoma brucei brucei was studied in mice which lacked CD4 or CD8 molecules and …

Several studies in mice have strengthened the active role played either by CD4+, CD8+ or
both T cell subsets in conferring resistance of Trypanosoma cruzi infection. To date, no …

Paiva, CN, Castelo-Branco, MTL, Lannes-Vieira, J., and Gattass, CR 1999. Trypanosoma
cruzi: Protective response of vaccinated mice is mediated by CD8+ cells, prevents signs of …

Mice vaccinated with CL-14, a non-infective and non-pathogenic clone isolated from
Trypanosoma cruzi CL strain, become protected against lethal challenge by infective …

In previous studies we have shown the protective value of T. cruzi excretory/secretory
antigens (ESA) as well as a synthetic peptide derived from the primary sequence of a 24 …

Immunization with a plasmid DNA containing the gene encoding the catalytic domain of
trans-sialidase (TS) elicits protective immune responses against experimental Trypanosoma …

Isotypic analysis of anti-parasite humoral responses of C57B1/6 and C3H (He) mice
surviving acute Trypanosoma cruzi infection showed that both mouse strains demonstrate …

The role of CD4+ T lymphocytes in the resistance of BALB/c mice to Trypanosoma cruzi was
examined by in vivo depletion using monoclonal anti‐CD4 antibodies (MoAbs)<. When the …

The role of T cell populations in immune control of Trypanosoma cruzi infection and
subsequent development of disease has been examined using gene knockout mice …