Antiviral efficacy and safety of molnupiravir against omicron variant infection: a randomized controlled clinical trial

R Zou, L Peng, D Shu, L Zhao, J Lan, G Tan… - Frontiers in …, 2022 - frontiersin.org
Background: The rapid worldwide spread of the Omicron variant of SARS-CoV-2 has
unleashed a new wave of COVID-19 outbreaks. The efficacy of molnupiravir, an approved …

Real-world effectiveness of sotrovimab for the treatment of SARS-CoV-2 infection during Omicron BA. 2 and BA. 5 subvariant predominance: A systematic literature …

M Drysdale, M Berktas, DC Gibbons, C Rolland… - Infection, 2024 - Springer
Purpose To evaluate clinical outcomes associated with sotrovimab use during Omicron BA.
2 and BA. 5 predominance. Methods Electronic databases were searched for observational …

Clinical efficacy of nirmatrelvir plus ritonavir in patients with COVID-19 and preexisting cardiovascular diseases

TH Liu, JY Wu, PY Huang, WH Hsu… - Expert Review of Anti …, 2024 - Taylor & Francis
Background This study assessed the clinical efficacy of nirmatrelvir plus ritonavir (NMV-r) in
treating patients with COVID-19 who have preexisting cardiovascular diseases (CVDs) …

Clinical Effectiveness of Ritonavir-Boosted Nirmatrelvir—A Literature Review

S Paltra, TOF Conrad - Advances in Respiratory Medicine, 2024 - mdpi.com
Highlights What are the main findings? Nirmatrelvir/Ritonavir, an oral treatment for COVID-
19, effectively reduces the risk of progressing to a more severe disease state for both the …

Real-World Utilization of Molnupiravir during the COVID-19 Omicron Surge in Israel

C Weil, T Bergroth, A Eisenberg, YO Whiteside… - Epidemiologia, 2023 - mdpi.com
Molnupiravir (MOV) was introduced in Israel in January 2022 during the SARS-CoV-2
Omicron surge for high-risk patients contraindicated for nirmatrelvir/ritonavir. This …

Nirmatrelvir/ritonavir and molnupiravir in the treatment of mild/moderate COVID-19: results of a real-life study

I Gentile, R Scotto, N Schiano Moriello, B Pinchera… - Vaccines, 2022 - mdpi.com
Molnupiravir and nirmatrelvir were the first available oral antivirals (OAs) active against
SARS-CoV-2. Trials evaluating the efficacy of OAs involved patients unvaccinated and …

Nirmatrelvir‐ritonavir therapy and COVID‐19 vaccination improve clinical outcomes of SARS‐CoV‐2 Omicron variant infection

T Qi, Y Jin, H Wang, Y Liao, T Liu, E Mao… - Journal of Medical …, 2023 - Wiley Online Library
To evaluate the effect of Nirmatrelvir‐ritonavir therapy and coronavirus disease 2019
(COVID‐19) vaccination on clinical outcomes of severe acute respiratory syndrome …

VV116 versus nirmatrelvir–ritonavir for oral treatment of Covid-19

Z Cao, W Gao, H Bao, H Feng, S Mei… - … England Journal of …, 2023 - Mass Medical Soc
Background Nirmatrelvir–ritonavir has been authorized for emergency use by many
countries for the treatment of coronavirus disease 2019 (Covid-19). However, the supply …

Efficacy and safety of molnupiravir in patients with Omicron variant vaccine breakthrough COVID-19 infection: a randomized, controlled trial

Y Liu, S Fan, A Xu, L Ge, X Wang, X Dong… - Frontiers in …, 2023 - frontiersin.org
Introduction: Randomized, controlled trials of molnupiravir in real-world use during the
Omicron wave are scarce. The frequency of hospitalization and death is low, so further …

Efficacy of Sotrovimab (SOT), Molnupiravir (MOL), and Nirmatrelvir/Ritponavir (N/R) and Tolerability of Molnupiravir in Outpatients at High Risk for Severe COVID-19

V Kauer, D Totschnig, F Waldenberger, M Augustin… - Viruses, 2023 - mdpi.com
Objective: The main goal of this study was to assess the potential clinical impact of an
outpatient administration of available antivirals including SOT, N/R, and MOL to COVID-19 …