Neglect is a common and frequently chronic form of child maltreatment that can compromise
child development and increase the risk of physical and psychological problems. In this …

The neurobiological mechanisms by which childhood maltreatment heightens vulnerability
to psychopathology remain poorly understood. It is likely that a complex interaction between …

Childhood maltreatment represents a significant risk factor for the development of a number
of mental and physical health outcomes. Converging evidence suggests that early adversity …

Background Research on early adversity, stress biology, and child development has grown
exponentially in recent years. Findings We review the current evidence for the hypothalamic …

The developing HPA axis is under strong social regulation in infancy and early childhood
and is vulnerable to perturbation in the absence of sensitive, responsive caregiving. Child …

This article reviews the evidence for theoretical models postulating that early adversity can
set in motion a deleterious developmental cascade, involving changes in hypothalamic …

Childhood adversity has been repeatedly and robustly linked to physical and mental illness
across the lifespan. Yet, the biological pathways through which this occurs remain unclear …

Maltreatment adversely impacts the development of children across a host of domains. One
way in which maltreatment may exert its deleterious effects is by becoming embedded in the …

Abnormal functioning of the hypothalamic-pituitary-adrenal (HPA) axis, a critical mammalian
stress response system, has been associated with emotional responses such as anxiety and …

Early severe stress and maltreatment produces a cascade of neurobiological events that
have the potential to cause enduring changes in brain development. These changes occur …