Type 2 diabetes mellitus results from the interaction of environmental factors with a
combination of genetic variants, most of which were hitherto unknown. A systematic search …

The genetic architecture of common traits, including the number, frequency, and effect sizes
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …

New strategies for prevention and treatment of type 2 diabetes (T2D) require improved
insight into disease etiology. We analyzed 386,731 common single-nucleotide …

betes) havealso beenexaminedinthe searchfortypeIIdiabetessusceptibility genes. Althoughvariantshavebeenidentifiedinmany…
, onlyafewhavebeen showntoassociate withdiabetesorimpaired proteinfunction (Fig. 1) …

The molecular mechanisms involved in the development of type 2 diabetes are poorly
understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 …

Meta-analyses of genome-wide association studies (GWAS) have identified more than 240
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …

Abstract The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide
association (GWA) scan on seven diseases, including the multifactorial autoimmune disease …

Abstract Type 1 diabetes (T1D) in children results from autoimmune destruction of
pancreatic beta cells, leading to insufficient production of insulin. A number of genetic …

Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …

Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has
been a formidable challenge. Adopting a genome-wide association strategy, we genotyped …