Single-cell analysis of prenatal and postnatal human cortical development

D Velmeshev, Y Perez, Z Yan, JE Valencia… - Science, 2023 - science.org
We analyzed> 700,000 single-nucleus RNA sequencing profiles from 106 donors during
prenatal and postnatal developmental stages and identified lineage-specific programs that …

Chromatin accessibility dynamics in a model of human forebrain development

AE Trevino, N Sinnott-Armstrong, J Andersen, SJ Yoon… - Science, 2020 - science.org
INTRODUCTION The cerebral cortex is responsible for higher-order functions in the nervous
system and has undergone substantial expansion in size in primates. The development of …

Spatiotemporal transcriptomic divergence across human and macaque brain development

Y Zhu, AMM Sousa, T Gao, M Skarica, M Li, G Santpere… - Science, 2018 - science.org
INTRODUCTION Improved understanding of how the developing human nervous system
differs from that of closely related nonhuman primates is fundamental for teasing out human …

Integrative functional genomic analysis of human brain development and neuropsychiatric risks

M Li, G Santpere, Y Imamura Kawasawa, OV Evgrafov… - Science, 2018 - science.org
INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes
us uniquely human. The development of the brain is a highly complex process, and this …

Transcriptomic diversity of cell types across the adult human brain

K Siletti, R Hodge, A Mossi Albiach, KW Lee, SL Ding… - Science, 2023 - science.org
The human brain directs complex behaviors, ranging from fine motor skills to abstract
intelligence, but the diversity of cell types that support these skills has not been fully …

Massively parallel characterization of regulatory elements in the developing human cortex

C Deng, S Whalen, M Steyert, R Ziffra, PF Przytycki… - Science, 2024 - science.org
Nucleotide changes in gene regulatory elements are important determinants of neuronal
development and diseases. Using massively parallel reporter assays in primary human cells …

Transcriptome and epigenome landscape of human cortical development modeled in organoids

A Amiri, G Coppola, S Scuderi, F Wu, T Roychowdhury… - Science, 2018 - science.org
INTRODUCTION The human cerebral cortex has undergone an extraordinary increase in
size and complexity during mammalian evolution. Cortical cell lineages are specified in the …

[HTML][HTML] Single-cell epigenomics reveals mechanisms of human cortical development

RS Ziffra, CN Kim, JM Ross, A Wilfert, TN Turner… - Nature, 2021 - nature.com
During mammalian development, differences in chromatin state coincide with cellular
differentiation and reflect changes in the gene regulatory landscape. In the developing brain …

Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex

TJ Nowakowski, A Bhaduri, AA Pollen, B Alvarado… - Science, 2017 - science.org
Systematic analyses of spatiotemporal gene expression trajectories during organogenesis
have been challenging because diverse cell types at different stages of maturation and …

Single-cell genomics identifies cell type–specific molecular changes in autism

D Velmeshev, L Schirmer, D Jung, M Haeussler… - Science, 2019 - science.org
Despite the clinical and genetic heterogeneity of autism, bulk gene expression studies show
that changes in the neocortex of autism patients converge on common genes and pathways …