Abnormalities of kidney and urinary tract development are the most common cause of end-
stage kidney failure in childhood in the United States. Over the past 20 years, the advent of …

The molecular regulation of the complex inductive events associated with formation of the
vertebrate excretory system has been progressively elucidated as a result of both genetic …

The mammalian kidney consists of highly specialised cells that function in an integrated
manner to maintain homeostasis of body fluids, electrolytes and nutrients. Formation of …

The mammalian kidney is a vital organ with considerable cellular complexity and functional
diversity. Kidney development is notable for requiring distinct but coincident tubulogenic …

As in most organs, the emerging theme in kidney development is the importance of cross-
talk between several tissues and cell lineages to allow morphogenesis to proceed in a …

The kidney is widely used to study the mechanisms of organogenesis. Its development
involves fundamental processes, such as epithelial branching, induced morphogenesis and …

Renal malformations are the major cause of renal failure during early childhood. They are
found in approximately 100 genetic syndromes. We review the embryologic development of …

The mechanisms underlying kidney development in mice and humans is an area of intense
study. Insights into kidney organogenesis have the potential to guide our understanding of …

The kidney plays an essential role during excretion of metabolic waste products,
maintenance of key homeostasis components such as ion concentrations and hormone …

Organogenesis of the kidney has been intensely studied for over a century. In recent years
advances in molecular techniques have not only made great inroads into exploring the …