Mammalian kidney development has helped elucidate the general concepts of
mesenchymal-epithelial interactions, inductive signaling, epithelial cell polarization, and …

The kidney is a model developmental system for understanding mesodermal patterning and
organogenesis, a process that requires regional specification along multiple body axes, the …

Human kidney function is underpinned by approximately 1,000,000 nephrons, although the
number varies substantially, and low nephron number is linked to disease. Human kidney …

Recent functional studies in mouse further illustrate the importance of the epithelial–
mesenchymal interaction between the ureteric bud epithelium and the metanephric …

The focus of this review is the normal and abnormal development of the kidney and lower
urinary tract; for convenience, we will refer to the whole system as the renal tract. The …

Abstract Development of the kidney serves as a paradigm to understand the mechanisms
underlying the formation of an organ. The first sign of kidney development is the interaction …

PURPOSE: The recent basic science literature is replete with new discoveries in the
molecular genetics of renal development. However, little of this information has filtered into …

Over the recent decades there has been extensive investigation into the genetic/molecular
regulation and cellular/molecular mechanisms of nephrogenesis and ultimate kidney …

Toward an etiological classification of developmental disorders of the kidney and upper
urinary tract. There are a large number of developmental disorders and syndromes that …

Kidney development is based on differential cell-type-specific expression of a vast number
of genes. While multiple critical genes and pathways have been elucidated, a genome-wide …