Critical determinants of cytokine storm and type I interferon response in COVID-19 pathogenesis

S Ramasamy, S Subbian - Clinical microbiology reviews, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19), a rapidly evolving pandemic worldwide with at least 68 million …

The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis
and is more devastating than any other previous infectious disease. It has affected a …

The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection

MS Qudus, M Tian, S Sirajuddin, S Liu… - Journal of Medical …, 2023 - Wiley Online Library
In patients with severe COVID‐19, acute respiratory distress syndrome (ARDS), multiple
organ dysfunction syndrome (MODS), and even mortality can result from cytokine storm …

The pathogenesis and treatment of theCytokine Storm'in COVID-19

Q Ye, B Wang, J Mao - Journal of infection, 2020 - Elsevier
Cytokine storm is a general term applied to maladaptive cytokine release in response to
infection and other stimuli. The pathogenesis is complex but includes loss of regulatory …

Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines

A Fara, Z Mitrev, RA Rosalia, BM Assas - Open biology, 2020 - royalsocietypublishing.org
Coronavirus disease 2019 (COVID-19) has swept the world, unlike any other pandemic in
the last 50 years. Our understanding of the disease has evolved rapidly since the outbreak; …

Cytokine storm in COVID-19: immunopathogenesis and therapy

C Zanza, T Romenskaya, AC Manetti, F Franceschi… - Medicina, 2022 - mdpi.com
A cytokine storm is a hyperinflammatory state secondary to the excessive production of
cytokines by a deregulated immune system. It manifests clinically as an influenza-like …

COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons

SH Nile, A Nile, J Qiu, L Li, X Jia, G Kai - Cytokine & growth factor reviews, 2020 - Elsevier
The outbreak of the novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2)
responsible for coronavirus disease 2019 (COVID-19) has developed into an …

The pro-inflammatory cytokines in COVID-19 pathogenesis: What goes wrong?

D Darif, I Hammi, A Kihel, IEI Saik, F Guessous… - Microbial …, 2021 - Elsevier
The outbreak of coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) infection, has emerged in China in December 2019 …

Emerging aspects of cytokine storm in COVID-19: The role of proinflammatory cytokines and therapeutic prospects

R Dharra, AK Sharma, S Datta - Cytokine, 2023 - Elsevier
COVID-19 has claimed millions of lives during the last 3 years since initial cases were
reported in Wuhan, China, in 2019. Patients with COVID-19 suffer from severe pneumonia …

The interplay between inflammatory pathways and COVID-19: A critical review on pathogenesis and therapeutic options

S Choudhary, K Sharma, O Silakari - Microbial pathogenesis, 2021 - Elsevier
Abstract COVID-19, caused by SARS-CoV-2, emerged as the deadliest outbreak that has
now become a serious health issue to mankind. Activation of inflammatory signaling …