Cholesterol, as an important component in mammalian cells, is efficient for viral entry,
replication, and assembly. Oxysterols especially hydroxylated cholesterols are recognized …

Efficient antiviral drug discovery has been a pressing issue of global public health concern
since the outbreak of coronavirus disease 2019. In recent years, numerous in vitro and in …

As an essential lipid, cholesterol is of great value in keeping cell homeostasis, being the
precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind …

With the frequent outbreaks of emerging infectious diseases in recent years, an effective
broad-spectrum antiviral drug is becoming an urgent need for global public health …

The metabolic interplay between hosts and viruses plays a crucial role in determining the
outcome of viral infection. Viruses reorchestrate the host's primary metabolic gene networks …

Hepatitis C virus (HCV), a single-stranded positive-sense RNA virus of the Flaviviridae
family, causes chronic liver diseases, including hepatitis, cirrhosis, and cancer. HCV …

Cholesterol and components of the cholesterol biosynthetic pathway have fundamental
roles in all mammalian cells. Hydroxylated forms of cholesterol are now emerging as …

Physiological cholesterol metabolism implies the generation of a series of oxidized
derivatives, whose oxysterols are by far the most investigated ones for their potential …

Interferons (IFN) are essential antiviral cytokines that establish the cellular antiviral state
through upregulation of hundreds of interferon-stimulated genes (ISGs), most of which have …

Cholesterol is essential for building and maintaining cell membranes and is critical for
several steps in the replication cycle of viruses, especially for enveloped viruses. In …