Neuroimmune–glia interactions have been implicated in the development of neuropathic
pain. Interleukin-27 (IL-27) is a cytokine that presents regulatory activity in inflammatory …

Cytokines, essential mediators of inflammatory and immune responses, play an important
role in the pathophysiological processes associated with neuropathic pain following …

Neuroinflammation is critically involved in nerve injury-induced neuropathic pain,
characterized by local and systemic increased levels of proinflammatory cytokines …

Neuropathic pain seriously affects people's life, but its mechanism is not clear. Interleukin-17
(IL-17) is a proinflammation cytokine and involved in pain regulation. Our previous study …

Pathological pain imposes a huge burden on the economy and the lives of patients. At
present, drugs used for the treatment of pathological pain have only modest efficacy and are …

Numerous studies have shown that pain sensation is affected by various immune molecules,
such as cytokines, in tissues comprising the sensory pathway. Specifically, it has been …

Immune cells are critical in promoting neuroinflammation and neuropathic pain and in
facilitating pain resolution, depending on their inflammatory and immunoregulatory cytokine …

Immunity and neuroinflammation play major roles in neuropathic pain. Spinal interleukin (IL)-
17A, as a mediator connecting innate and adaptive immunity, has been shown to be an …

Central neuroinflammation is important in the pathophysiological processes of neuropathic
pain following peripheral nerve injury. Recently, interleukin-17 (IL-17) has been detected in …

Abstract Interleukin-17 (IL-17) is involved in a wide range of inflammatory disorders and in
recruitment of inflammatory cells to injury sites. A recent study of IL-17 knock-out mice …