A 3D vascularized bone remodeling model combining osteoblasts and osteoclasts in a CaP nanoparticle-enriched matrix
Aim: We aimed to establish a 3D vascularized in vitro bone remodeling model. Materials &
methods: Human umbilical endothelial cells (HUVECs), bone marrow mesenchymal stem …
methods: Human umbilical endothelial cells (HUVECs), bone marrow mesenchymal stem …
Endothelial cells support osteogenesis in an in vitro vascularized bone model developed by 3D bioprinting
Bone is a highly vascularized tissue, in which vascularization and mineralization are
concurrent processes during skeletal development. Indeed, both components should be …
concurrent processes during skeletal development. Indeed, both components should be …
Enhanced bone tissue regeneration of a biomimetic cellular scaffold with co‐cultured MSCs‐derived osteogenic and angiogenic cells
L Li, J Li, Q Zou, Y Zuo, B Cai, Y Li - Cell proliferation, 2019 - Wiley Online Library
Objectives The bone tissue engineering primarily focuses on three‐dimensional co‐culture
systems, which physical and biological properties resemble the cell matrix of actual tissues …
systems, which physical and biological properties resemble the cell matrix of actual tissues …
Endothelial cells enhance the in vivo bone-forming ability of osteogenic cell sheets
Addressing the problem of vascularization is of vital importance when engineering three-
dimensional (3D) tissues. Endothelial cells are increasingly used in tissue-engineered …
dimensional (3D) tissues. Endothelial cells are increasingly used in tissue-engineered …
Three-dimensional co-culture of peripheral blood-derived mesenchymal stem cells and endothelial progenitor cells for bone regeneration
Engraftment of tissue-engineered bone plays a pivotal role in the treatment of large bone
defects. However, promoting thorough vascularization in the central area of tissue …
defects. However, promoting thorough vascularization in the central area of tissue …
C ollagen hydrogel scaffold promotes mesenchymal stem cell and endothelial cell coculture for bone tissue engineering
BNB Nguyen, RA Moriarty… - … Research Part A, 2017 - Wiley Online Library
The generation of functional, vascularized tissues is a key challenge for the field of tissue
engineering. Before clinical implantations of such tissue engineered bone constructs can …
engineering. Before clinical implantations of such tissue engineered bone constructs can …
In vitro model of vascularized bone: synergizing vascular development and osteogenesis
Tissue engineering provides unique opportunities for regenerating diseased or damaged
tissues using cells obtained from tissue biopsies. Tissue engineered grafts can also be used …
tissues using cells obtained from tissue biopsies. Tissue engineered grafts can also be used …
Modeling vascularized bone regeneration within a porous biodegradable CaP scaffold loaded with growth factors
Osteogenetic microenvironment is a complex constitution in which extracellular matrix
(ECM) molecules, stem cells and growth factors each interact to direct the coordinate …
(ECM) molecules, stem cells and growth factors each interact to direct the coordinate …
Human in vitro 3D co-culture model to engineer vascularized bone-mimicking tissues combining computational tools and statistical experimental approach
The generation of functional, vascularized tissues is a key challenge for both tissue
engineering applications and the development of advanced in vitro models analyzing …
engineering applications and the development of advanced in vitro models analyzing …
Effect of donor variation on osteogenesis and vasculogenesis in hydrogel cocultures
I Pennings, LA van Dijk, J van Huuksloot… - Journal of tissue …, 2019 - Wiley Online Library
To introduce a functional vascular network into tissue‐engineered bone equivalents, human
endothelial colony forming cells (ECFCs) and multipotent mesenchymal stromal cells …
endothelial colony forming cells (ECFCs) and multipotent mesenchymal stromal cells …