Progress and pitfalls in the quest for effective SARS-CoV-2 (COVID-19) vaccines

KL Flanagan, E Best, NW Crawford, M Giles… - Frontiers in …, 2020 - frontiersin.org
There are currently around 200 SARS-CoV-2 candidate vaccines in preclinical and clinical
trials throughout the world. The various candidates employ a range of vaccine strategies …

[HTML][HTML] The immunology of SARS-CoV-2 infections and vaccines

L Grigoryan, B Pulendran - Seminars in immunology, 2020 - Elsevier
Abstract SARS-CoV-2, the virus that causes COVID-19, emerged in late 2019, and was
declared a global pandemic on March 11th 2020. With over 50 million cases and 1.2 million …

Efforts at COVID-19 vaccine development: challenges and successes

A Haque, AB Pant - Vaccines, 2020 - mdpi.com
The rapid spread of SARS-CoV-2, the new coronavirus (CoV), throughout the globe poses a
daunting public health emergency. Different preventive efforts have been undertaken in …

[HTML][HTML] SARS-CoV-2 vaccines in advanced clinical trials: Where do we stand?

S Chakraborty, V Mallajosyula, CM Tato, GS Tan… - Advanced drug delivery …, 2021 - Elsevier
The ongoing SARS-CoV-2 pandemic has led to the focused application of resources and
scientific expertise toward the goal of developing investigational vaccines to prevent COVID …

The COVID-19 vaccine development: a pandemic paradigm

DC Carneiro, JD Sousa, JP Monteiro-Cunha - Virus Research, 2021 - Elsevier
COVID-19 pandemic has resulted in millions of deaths and a social-economic crisis. A
worldwide effort was made to develop efficient vaccines for this disease. A vaccine should …

[HTML][HTML] COVID-19 vaccines: modes of immune activation and future challenges

JR Teijaro, DL Farber - Nature Reviews Immunology, 2021 - nature.com
The new vaccines against SARS-CoV-2 are novel in terms of specificity, their wide
dissemination across the global population and the inclusion of newly licensed mRNA …

COVID-19 vaccines: implementation, limitations and opportunities

DD Richman - Global health & medicine, 2021 - jstage.jst.go.jp
The speed of development and the magnitude of efficacy of recently developed vaccines
directed against SARS-CoV-2 has been truly remarkable. This editorial will not summarize …

COVID-19: Mechanisms of vaccination and immunity

DE Speiser, MF Bachmann - Vaccines, 2020 - mdpi.com
Vaccines are needed to protect from SARS-CoV-2, the virus causing COVID-19. Vaccines
that induce large quantities of high affinity virus-neutralizing antibodies may optimally …

[PDF][PDF] Approaches and challenges in SARS-CoV-2 vaccine development

G Dagotto, J Yu, DH Barouch - Cell host & microbe, 2020 - cell.com
The explosive spread of SARS-CoV-2 suggests that a vaccine will be required to end this
global pandemic. Progress in SARS-CoV-2 vaccine development to date has been faster …

[HTML][HTML] Targets and strategies for vaccine development against SARS-CoV-2

JA Malik, AH Mulla, T Farooqi, FH Pottoo… - Biomedicine & …, 2021 - Elsevier
Abstract The SARS-CoV-2, previously called a novel coronavirus, that broke out in the
Wuhan city of China caused a significant number of morbidity and mortality in the world. It is …