Admixture mapping reveals the association between Native American ancestry at 3q13. 11 and reduced risk of Alzheimer's disease in Caribbean Hispanics

ARVR Horimoto, D Xue, TA Thornton… - Alzheimer's Research & …, 2021 - Springer
Background Genetic studies have primarily been conducted in European ancestry
populations, identifying dozens of loci associated with late-onset Alzheimer's disease (AD) …

[PDF][PDF] Admixture mapping implicates 13q33. 3 as ancestry-of-origin locus for Alzheimer disease in Hispanic and Latino populations

ARVR Horimoto, LA Boyken, EE Blue, KE Grinde… - Human Genetics and …, 2023 - cell.com
Alzheimer disease (AD) is the most common form of senile dementia, with high incidence
late in life in many populations including Caribbean Hispanic (CH) populations. Such …

Admixture mapping identifies novel Alzheimer's disease risk regions in African Americans

F Rajabli, G Tosto, KL Hamilton‐Nelson… - Alzheimer's & …, 2023 - Wiley Online Library
Background This study used admixture mapping to prioritize the genetic regions associated
with Alzheimer's disease (AD) in African American (AA) individuals, followed by ancestry …

Global and local ancestry in African‐Americans: implications for Alzheimer's disease risk

TJ Hohman, JN Cooke‐Bailey, C Reitz… - Alzheimer's & …, 2016 - Wiley Online Library
Abstract Introduction African‐American (AA) individuals have a higher risk for late‐onset
Alzheimer's disease (LOAD) than Americans of primarily European ancestry (EA). Recently …

The power of representation: Statistical analysis of diversity in US Alzheimer's disease genetics data

D Xue, EE Blue, MP Conomos… - Alzheimer's & Dementia …, 2024 - Wiley Online Library
INTRODUCTION Alzheimer's disease (AD) is a complex disease influenced by genetics and
environment. More than 75 susceptibility loci have been linked to late‐onset AD, but most of …

The Caribbean-Hispanic Alzheimer's brain transcriptome reveals ancestry-specific disease mechanisms

D Felsky, S Sariya, I Santa-Maria, L French… - Biorxiv, 2020 - biorxiv.org
Ethnicity impacts Alzheimer's disease risk, especially among Caribbean-Hispanics. We
report the first RNA-sequencing analysis of brain tissue from 45 Alzheimer's disease and …

[HTML][HTML] Linkage of Alzheimer disease families with Puerto Rican ancestry identifies a chromosome 9 locus

F Rajabli, BE Feliciano-Astacio, HN Cukier, L Wang… - Neurobiology of …, 2021 - Elsevier
The genetic admixture of Caribbean Hispanics provides an opportunity to discover novel
genetic factors in Alzheimer disease (AD). We sought to identify genetic variants for AD …

Admixture Mapping of Alzheimer's disease in Caribbean Hispanics identifies a new locus on 22q13. 1

C Kizil, S Sariya, YA Kim, F Rajabli, E Martin… - Molecular …, 2022 - nature.com
Late-onset Alzheimer's disease (LOAD) is significantly more frequent in Hispanics than in
non-Hispanic Whites. Ancestry may explain these differences across ethnic groups. To this …

Genetics of Alzheimer's Disease in the African American Population

MW Logue, S Dasgupta, LA Farrer - Journal of Clinical Medicine, 2023 - mdpi.com
Black/African American (AA) individuals have a higher risk of Alzheimer's disease (AD) than
White non-Hispanic persons of European ancestry (EUR) for reasons that may include …

[HTML][HTML] Genetic analyses in multiplex families confirms chromosome 5q35 as a risk locus for Alzheimer's Disease in individuals of African Ancestry

K Nuytemans, F Rajabli, M Jean-Francois, JT Kurup… - Neurobiology of …, 2024 - Elsevier
There is a paucity of genetic studies of Alzheimer Disease (AD) in individuals of African
Ancestry, despite evidence suggesting increased risk of AD in the African American (AA) …