Optimization and application of particle beam high‐performance liquid chromatography/mass spectrometry to compounds of pharmaceutical interest

RD Voyksner, CS Smith… - … & environmental mass …, 1990 - Wiley Online Library
Particle beam high‐performance liquid chromatography/mass spectrometry (HPLC/MS)
parameters were optimized for the sensitive analysis of several drugs in agricultural …

Particle beam liquid chromatography–mass spectrometry: instrumentation and applications. A review

CS Creaser, JW Stygall - Analyst, 1993 - pubs.rsc.org
The coupling of liquid chromatography to mass spectrometry (LC-MS) has been the subject
of intense research since the pioneering work of Tal'roze et aZ. 1 over 20 years ago. On-line …

Investigation of enhanced ion abundances from a carrier process in high-performance liquid chromatography particle beam mass spectrometry

TA Bellar, TD Behymer, WL Budde - Journal of the American …, 1990 - ACS Publications
Enhancements in ion abundances in high-performance liquid chromatography (HPLC)
particle beam (PB) mass spectrometry were observed during coelution or when certain …

Applications of hyphenated LC‐MS techniques in pharmaceutical analysis

J Ermer, M Vogel - Biomedical chromatography, 2000 - Wiley Online Library
In pharmaceutical analysis, ie the analytical development and quality control of drug
substances and dosage forms, mass spectrometry (MS) combined with chromatographic …

High-performance liquid chromatography/mass spectrometry: state of the art for the drug analysis laboratory.

LD Bowers - Clinical chemistry, 1989 - academic.oup.com
The combination of HPLC and mass spectrometry has great promise for the toxicology
laboratory. In the past five years, significant progress has been made toward producing a …

Quantitative analysis of pharmaceuticals in biological fluids using high-performance liquid chromatography coupled to mass spectrometry: a review

RS Plumb, GJ Dear, DN Mallett, DM Higton… - Xenobiotica, 2001 - Taylor & Francis
1. The development of bio-analysis of drug molecules over the last 10 years is reviewed,
focusing on advances in sample preparation, liquid chromatography and detection. 2 …

Development of a paper spray mass spectrometry cartridge with integrated solid phase extraction for bioanalysis

C Zhang, NE Manicke - Analytical chemistry, 2015 - ACS Publications
A novel paper spray cartridge with an integrated solid phase extraction (SPE) column is
described. The cartridge performs extraction and pre-concentration, as well as sample …

Determination of veterinary drug residues by liquid chromatography and tandem mass spectrometry

G Balizs, A Hewitt - Analytica Chimica Acta, 2003 - Elsevier
This paper describes the principles, the current technology and the applications of HPLC
and tandem mass spectrometry (LC–MS–MS) in the analysis of veterinary drug residues …

Rapid screening of active ingredients in drugs by mass spectrometry with low-temperature plasma probe

Y Liu, Z Lin, S Zhang, C Yang, X Zhang - Analytical and bioanalytical …, 2009 - Springer
A high-throughput method for rapid screening of active ingredients in drugs has been
developed with mass spectrometry coupled to a low-temperature plasma (LTP) probe ion …

Evaluation of several solid phase extraction liquid chromatography/tandem mass spectrometry on‐line configurations for high‐throughput analysis of acidic and basic …

CR Mallet, JR Mazzeo, U Neue - Rapid Communications in …, 2001 - Wiley Online Library
Abstract Several configurations using 6‐and 10‐port switching valves were studied for high
flow, on‐line extraction of rat plasma coupled to an electrospray triple quadrupole mass …