Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation
Common genetic risk for neuropsychiatric disorders is enriched in regulatory elements
active during cortical neurogenesis. However, it remains poorly understood as to how these …
active during cortical neurogenesis. However, it remains poorly understood as to how these …
Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes
Mutations in gene regulatory elements have been associated with a wide range of complex
neuropsychiatric disorders. However, due to their cell-type specificity and difficulties in …
neuropsychiatric disorders. However, due to their cell-type specificity and difficulties in …
An atlas of chromatin accessibility in the adult human brain
Most common genetic risk variants associated with neuropsychiatric disease are noncoding
and are thought to exert their effects by disrupting the function of cis regulatory elements …
and are thought to exert their effects by disrupting the function of cis regulatory elements …
[HTML][HTML] Single-cell epigenomics reveals mechanisms of human cortical development
During mammalian development, differences in chromatin state coincide with cellular
differentiation and reflect changes in the gene regulatory landscape. In the developing brain …
differentiation and reflect changes in the gene regulatory landscape. In the developing brain …
Allele-specific open chromatin in human iPSC neurons elucidates functional disease variants
Most neuropsychiatric disease risk variants are in noncoding sequences and lack functional
interpretation. Because regulatory sequences often reside in open chromatin, we reasoned …
interpretation. Because regulatory sequences often reside in open chromatin, we reasoned …
Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility
H Won, J Huang, CK Opland, CL Hartl… - Nature …, 2019 - nature.com
Modern genetic studies indicate that human brain evolution is driven primarily by changes in
gene regulation, which requires understanding the biological function of largely non-coding …
gene regulation, which requires understanding the biological function of largely non-coding …
Common schizophrenia risk variants are enriched in open chromatin regions of human glutamatergic neurons
The chromatin landscape of human brain cells encompasses key information to
understanding brain function. Here we use ATAC-seq to profile the chromatin structure in …
understanding brain function. Here we use ATAC-seq to profile the chromatin structure in …
Brain-trait-associated variants impact cell-type-specific gene regulation during neurogenesis
N Aygün, AL Elwell, D Liang, MJ Lafferty… - The American Journal of …, 2021 - cell.com
Interpretation of the function of non-coding risk loci for neuropsychiatric disorders and brain-
relevant traits via gene expression and alternative splicing quantitative trait locus (e/sQTL) …
relevant traits via gene expression and alternative splicing quantitative trait locus (e/sQTL) …
A comparative atlas of single-cell chromatin accessibility in the human brain
Recent advances in single-cell transcriptomics have illuminated the diverse neuronal and
glial cell types within the human brain. However, the regulatory programs governing cell …
glial cell types within the human brain. However, the regulatory programs governing cell …
Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders
Cellular heterogeneity in the human brain obscures the identification of robust cellular
regulatory networks, which is necessary to understand the function of non-coding elements …
regulatory networks, which is necessary to understand the function of non-coding elements …