The thyroid TRK oncogenes are generated by chromosomal rearrangements juxtaposing
the neurotrophic tyrosine receptor kinase type 1 (NTRK1) tyrosine kinase domain to foreign …

The thyroid TRK-T3 oncogene, produced by a chromosomal translocation, is a chimeric,
constitutively activated version of the NTRK1/NGF receptor and it is able to transform …

Genetic analysis of human papillary thyroid carcinomas (PTC) has revealed unique
chromosomal translocations that form oncogenic fusion proteins and promote thyroid …

The thyroid TRK-T3 oncogene results from the fusion of the tyrosine kinase (TK) domain of
NTRK1 (one of the receptors for the Nerve Growth Factor) on chromosome 1 to sequences …

The TRK-T3 oncoprotein, isolated from a human papillary thyroid tumor, arises from the
fusion between the N-terminal domain of the TFG gene and the tyrosine kinase domain of …

TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC);
they arise from the fusion of the 3′ terminal sequences of the NTRK1/NGF receptor gene …

Oncogenic rearrangements of the NTRK1 gene (also designated TRKA), encoding one of
the receptors for the nerve growth factor, are frequently detected in thyroid carcinomas. Such …

Proto-TRK and proto-RET genes encode receptor type tyrosine kinases. Oncogenic
rearrangements of both proto-oncogenes have been detected with a significant frequency in …

The receptor tyrosine kinase RET functions as the signal transducing receptor for the GDNF
(for “glial cell-derived neurotrophic factors”) family of ligands. Mutations in the RET gene …

TRK‐T1 oncogene is generated by the rearrangement of the NGF receptor TrkA with TPR.
This gives rise to the constitutive tyrosine autophosphorylation and activation of the kinase …