Serum proteomic profiles reflect the stages of myxomatous mitral valve disease in dogs

D Rešetar Maslov, V Farkaš, I Rubić, J Kuleš… - International journal of …, 2023 - mdpi.com
Canine myxomatous mitral valve disease (MMVD) is similar to Barlow's form of MMVD in
humans. These valvulopathies are complex, with varying speeds of progression. We …

Differential protein expression between normal, early‐stage, and late‐stage myxomatous mitral valves from dogs

CMR Lacerda, S Disatian… - PROTEOMICS–Clinical …, 2009 - Wiley Online Library
Valvular heart disease accounts for over 20 000 deaths and 90 000 hospitalizations yearly
in the United States. Myxomatous valve disease (MVD) is the most common disease of the …

Proteomics reveals plasma protein SERPINH1 as a potential diagnostic biomarkers for myxomatous mitral valve disease stage B2

Q Zhou, Z Wu, L Li, H Zhou, Y Chen, S Guo, Y Guo… - Journal of …, 2023 - Elsevier
Background Although it is well known that myxomatous mitral valve disease stage B2
(MMVD stage B2) is predominantly characterized by ECM remodeling of the mitral valve …

Comparative transcriptomic profiling and gene expression for myxomatous mitral valve disease in the dog and human

GR Markby, KM Summers, VE MacRae… - Veterinary …, 2017 - mdpi.com
Myxomatous mitral valve disease is the single most important mitral valve disease in both
dogs and humans. In the case of the dog it is ubiquitous, such that all aged dogs will have …

Serum proteomic changes in dogs with different stages of chronic heart failure

A Saril, M Kocaturk, K Shimada, A Uemura, E Akgün… - Animals, 2022 - mdpi.com
Simple Summary Canine MMVD is a progressive chronic disease with variable clinical
signs, with some patients remaining completely asymptomatic while others develop CHF …

RNA sequencing provides novel insights into the pathogenesis of naturally occurring myxomatous mitral valve disease stage B1 in beagle dogs

TS Kim, CY Hong, SJ Oh, YH Choe, TS Hwang, J Kim… - Plos one, 2024 - journals.plos.org
Myxomatous mitral valve disease (MMVD) is the most common cardiovascular disorder in
dogs with a high prevalence, accounting for approximately 75% of all canine heart disease …

Disease severity-associated gene expression in canine myxomatous mitral valve disease is dominated by TGFβ signaling

GR Markby, VE Macrae, KM Summers… - Frontiers in …, 2020 - frontiersin.org
Myxomatous mitral valve disease (MMVD) is the most common acquired canine
cardiovascular disease and shares many similarities with human mitral valvulopathies …

Proteomic analysis of the serum in dogs with pulmonary hypertension secondary to myxomatous mitral valve disease: the preliminary study

S Sakarin, A Rungsipipat, S Roytrakul… - Frontiers in Veterinary …, 2024 - frontiersin.org
Background Pulmonary hypertension (PH) is a common complication in dogs with
myxomatous mitral valve disease (MMVD), characterized by elevated blood pressure in …

Serum proteomic profiles in CKCS with Mitral valve disease

C Locatelli, C Piras, G Riscazzi, I Alloggio… - BMC veterinary …, 2016 - Springer
Background Myxomatous mitral valve disease (MVD) is the most common acquired heart
disease in dogs, and the Cavalier King Charles Spaniel (CKCS) is the most studied breed …

Serum proteome profiling in canine chronic valve disease using a TMT-based quantitative proteomics approach

J Kuleš, P Bilić, A Horvatić, A Kovačević, N Guillemin… - Journal of …, 2020 - Elsevier
Chronic valve disease (CVD) is the most common clinically significant heart disease of dogs,
affecting 20 to 40% of dogs. The aim of this study was to evaluate the serum protein profile of …