In an effort to identify a cohort of patients who might benefit from the early administration of
novel therapies designed to modulate the endogenous host inflammatory response, an …

Another change has occurred in the last decade: we have learned a great deal about the
cascade of inflammatory mediators that underlies sepsis. There appears to be a common …

Although the clinical definition of microbial sepsis is still controversial, definition can be
derived from its well-known clinical picture [4, 11, 16] and from the underlying …

Much research over the past 30 to 40 years has shown that the inflammatory response,
while critical for host defense during microbial infection, may itself play a central role in the …

The number of occurrences of sepsis and sepsis syndrome has been rising for the last 20
years. 9, 13 Current estimates indicate that there are approximately 500,000 cases of sepsis …

Sepsis, by definition, requires the presence of an infection as the cause of the systemic
inflammatory response. At its inception, it may be difficult to distinguish sepsis from non …

Over recent years, major advances have been made in our understanding of the sepsis
response, its origins, mediators, effects, and consequences. Ongoing research continues to …

In August 1991, leadership of the American College of Chest Physicians and the Society of
Critical Care Medicine met with the goal of agreeing on a set of definitions that could be …

Pathophysiologic basis of sepsis: Considerations for future... : Critical Care Medicine
Pathophysiologic basis of sepsis: Considerations for future strategies of intervention : Critical …

Sepsis is a serious condition that is associated with high mortality despite advanced modern
medical treatment. Recent years have witnessed novel paradigms describing host …