Current research for a vaccine against Lassa hemorrhagic fever virus

BM Warner, D Safronetz, DR Stein - Drug design, development and …, 2018 - Taylor & Francis
Lassa virus (LASV) is a rodent-borne arenavirus endemic to several West African countries
that causes Lassa fever (LF). LF is typically mild but it can cause severe disease …

[HTML][HTML] Vaccine platforms for the prevention of Lassa fever

J Purushotham, T Lambe, SC Gilbert - Immunology Letters, 2019 - Elsevier
Lassa fever is an acute viral haemorrhagic illness caused by Lassa virus (LASV), which is
endemic throughout much of West Africa. The virus primarily circulates in the Mastomys …

Advanced vaccine candidates for Lassa fever

IS Lukashevich - Viruses, 2012 - mdpi.com
Lassa virus (LASV) is the most prominent human pathogen of the Arenaviridae. The virus is
transmitted to humans by a rodent reservoir, Mastomys natalensis, and is capable of causing …

Lassa fever—the road ahead

RF Garry - Nature Reviews Microbiology, 2023 - nature.com
Lassa virus (LASV) is endemic in the rodent populations of Sierra Leone, Nigeria and other
countries in West Africa. Spillover to humans occurs frequently and results in Lassa fever, a …

The search for animal models for Lassa fever vaccine development

IS Lukashevich - Expert review of vaccines, 2013 - Taylor & Francis
Lassa virus (LASV) is the most prevalent arenavirus in West Africa and is responsible for
several hundred thousand infections and thousands of deaths annually. The sizeable …

Pathogenicity and virulence mechanisms of Lassa virus and its animal modeling, diagnostic, prophylactic, and therapeutic developments

HL Murphy, H Ly - Virulence, 2021 - Taylor & Francis
Lassa fever (LF) is a deadly viral hemorrhagic disease that is endemic to West Africa. The
causative agent of LF is Lassa virus (LASV), which causes approximately 300,000 infections …

Understanding immune responses to Lassa virus infection and to its candidate vaccines

H Murphy, H Ly - Vaccines, 2022 - mdpi.com
Lassa fever (LF) is a deadly viral hemorrhagic fever disease that is endemic in several
countries in West Africa. It is caused by Lassa virus (LASV), which has been estimated to be …

Vaccine platforms to control Lassa fever

IS Lukashevich, P Pushko - Expert Review of Vaccines, 2016 - Taylor & Francis
ABSTRACT Introduction: Lassa virus (LASV), the most prominent human pathogen of the
Arenaviridae, is transmitted to humans from infected rodents and can cause Lassa Fever …

Adenoviral vector-based vaccine is fully protective against lethal Lassa fever challenge in Hartley guinea pigs

J Maruyama, EJ Mateer, JT Manning, R Sattler… - Vaccine, 2019 - Elsevier
Lassa virus (LASV), the causative agent of Lassa fever (LF), was first identified in 1969.
Since then, outbreaks in the endemic countries of Nigeria, Liberia, and Sierra Leone occur …

Lassa virus-like particles displaying all major immunological determinants as a vaccine candidate for Lassa hemorrhagic fever

LM Branco, JN Grove, FJ Geske, ML Boisen, IJ Muncy… - Virology journal, 2010 - Springer
Background Lassa fever is a neglected tropical disease with significant impact on the health
care system, society, and economy of Western and Central African nations where it is …