The spread of COVID-19 infection continues due to the emergence of multiple transmissible
and immune-evasive variants of the SARS-CoV-2 virus. Although various vaccines have …

Drug repurposing approach was applied to find a potent antiviral agent against RNA viruses
such as SARS-CoV-2, influenza viruses and dengue virus with a concise strategy of small …

Abstract β-DN 4-hydroxycytidine (NHC, EIDD-1931) is a nucleoside analogue that exhibits
broad spectrum antiviral activity against a variety of RNA viruses. Herein, we report the …

The spread of COVID-19 continues due to genetic variation in SARS-CoV-2. Highly mutated
variants of SARS-CoV-2 have an increased transmissibility and immune evasion. Due to the …

Coronavirus disease 2019 (COVID-19) is an emerging global pandemic with severe
morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 …

A class of pyrimidine thioglycoside analogs (6a–h) were synthesized from a reaction of 2-
cyano-3, 3-dimercapto-N-arylacrylamide (2a–d) and thiourea to produce the corresponding …

The pandemic caused by the novel betacoronavirus SARS-CoV-2 has already claimed more
than 3.5 million lives. Despite the development and use of anti-COVID-19 vaccines, the …

Coronaviruses (CoVs) are positive-sense RNA enveloped viruses, members of the family
Coronaviridae, that cause infections in a broad range of mammals including humans …

Synthetic nucleoside or nucleotide analogues played a key role to the development of
antiviral agents in past decades. However, low membrane permeability and insufficient …

Nucleobases serve as essential molecular frameworks present in both natural and synthetic
compounds that exhibit notable antiviral activity. Through molecular modifications, novel …