Simple Summary The interaction between cluster of differentiation 47 (CD47) on cancer
cells and signal regulatory protein alpha (SIRPα) on immune cells, such as macrophages …

CD47 is an immunoglobulin that is overexpressed on the surface of many types of cancer
cells. CD47 forms a signaling complex with signal-regulatory protein α (SIRPα), enabling the …

The success of cancer immunotherapy has generated tremendous interest in identifying new
immunotherapeutic targets. To date, the majority of therapies have focussed on stimulating …

CD47 is a membrane receptor that plays pivotal roles in many pathophysiological
processes, including infection, inflammation, cell spreading, proliferation, and apoptosis. We …

Tumor cells evade immune surveillance through direct or indirect interactions with various
types of immune cell, with much recent attention being focused on modifying immune cell …

Transgenic CD47 overexpression is an encouraging approach to ameliorating xenograft
rejection and alloresponses to pluripotent stem cells, and the efficacy correlates with the …

Macrophages clear pathogens and damaged or aged cells from the blood stream via
phagocytosis. Cell-surface CD47 interacts with its receptor on macrophages, SIRPα, to …

When expressed on the surface of cells, CD47 inhibits phagocytosis of these cells by
phagocytes. Most human cancers overexpress CD47, and antibodies to CD47 have shown …

Immunometabolic reprogramming due to adenosine produced by CD73 (encoded by the 5'-
ectonucleotidase gene NT5E) is a recognized immunosuppressive mechanism contributing …

Purpose: Natural killer (NK) cells play a critical role in tumor immunosurveillance. Multiple
activating and inhibitory receptors (IR) regulate NK-cell–mediated tumor control. The IR T …