Immune-epidemiological parameters of the novel coronavirus–a perspective

A Saghazadeh, N Rezaei - Expert review of clinical immunology, 2020 - Taylor & Francis
Introduction At the end of 2019, Wuhan, a city in China with a population of about 11 million,
witnessed the outbreak of unusual pneumonia. As of 29 March 2020, the disease has …

Immune responses in mildly versus critically ill COVID-19 patients

H Nasrollahi, AG Talepoor, Z Saleh… - Frontiers in …, 2023 - frontiersin.org
The current coronavirus pandemic (COVID-19), caused by SARS-CoV-2, has had
devastating effects on the global health and economic system. The cellular and molecular …

Pathophysiology and clinical management of coronavirus disease (COVID-19): a mini-review

Y Zhu, L Sharma, D Chang - Frontiers in Immunology, 2023 - frontiersin.org
An unprecedented global pandemic caused by a novel coronavirus named SARS-CoV-2
has created a severe healthcare threat and become one of the biggest challenges to human …

Early cross-coronavirus reactive signatures of humoral immunity against COVID-19

P Kaplonek, C Wang, Y Bartsch, S Fischinger… - Science …, 2021 - science.org
The introduction of vaccines has inspired hope in the battle against SARS-CoV-2. However,
the emergence of viral variants, in the absence of potent antivirals, has left the world …

Severe acute respiratory syndrome coronavirus 2–induced immune activation and death of monocyte-derived human macrophages and dendritic cells

J Zheng, Y Wang, K Li, DK Meyerholz… - The Journal of …, 2021 - academic.oup.com
Studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–infected
patients and experimentally infected animals indicate a critical role for augmented …

Dysregulated innate and adaptive immune responses discriminate disease severity in COVID-19

NAF Janssen, I Grondman… - The Journal of …, 2021 - academic.oup.com
The clinical spectrum of COVID-19 varies and the differences in host response
characterizing this variation have not been fully elucidated. COVID-19 disease severity …

SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)

AD Proal, MB VanElzakker, S Aleman, K Bach… - Nature …, 2023 - nature.com
Millions of people are suffering from Long COVID or post-acute sequelae of COVID-19
(PASC). Several biological factors have emerged as potential drivers of PASC pathology …

COVID-19: immunopathology and its implications for therapy

X Cao - Nature reviews immunology, 2020 - nature.com
Severe coronavirus disease 2019 (COVID-19) is characterized by pneumonia, lymphopenia,
exhausted lymphocytes and a cytokine storm. Significant antibody production is observed; …

Activation and evasion of type I interferon responses by SARS-CoV-2

X Lei, X Dong, R Ma, W Wang, X Xiao, Z Tian… - Nature …, 2020 - nature.com
The pandemic of COVID-19 has posed an unprecedented threat to global public health.
However, the interplay between the viral pathogen of COVID-19, SARS-CoV-2, and host …

[HTML][HTML] Imbalanced host response to SARS-CoV-2 drives development of COVID-19

D Blanco-Melo, BE Nilsson-Payant, WC Liu, S Uhl… - Cell, 2020 - cell.com
Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to
humanity. Because of its recent emergence, there is a paucity of information regarding viral …