Seeking a spotless mind: extinction, deconsolidation, and erasure of fear memory

S Maren - Neuron, 2011 - cell.com
Learning to contend with threats in the environment is essential to survival, but dysregulation
of memories for traumatic events can lead to disabling psychopathology. Recent years have …

Implications of memory modulation for post-traumatic stress and fear disorders

RG Parsons, KJ Ressler - Nature neuroscience, 2013 - nature.com
Post-traumatic stress disorder, panic disorder and phobia manifest in ways that are
consistent with an uncontrollable state of fear. Their development involves heredity, previous …

Neural and cellular mechanisms of fear and extinction memory formation

CA Orsini, S Maren - Neuroscience & Biobehavioral Reviews, 2012 - Elsevier
Over the course of natural history, countless animal species have evolved adaptive
behavioral systems to cope with dangerous situations and promote survival. Emotional …

Prefrontal inputs to the amygdala instruct fear extinction memory formation

O Bukalo, CR Pinard, S Silverstein, C Brehm… - Science …, 2015 - science.org
Persistent anxiety after a psychological trauma is a hallmark of many anxiety disorders.
However, the neural circuits mediating the extinction of traumatic fear memories remain …

Neuroscience of fear extinction: implications for assessment and treatment of fear-based and anxiety related disorders

MR Milad, BL Rosenbaum, NM Simon - Behaviour research and therapy, 2014 - Elsevier
Current exposure-based therapies aimed to reduce pathological fear and anxiety are now
amongst the most effective interventions for trauma and anxiety related disorders …

Unrelenting fear under stress: neural circuits and mechanisms for the immediate extinction deficit

S Maren - Frontiers in Systems Neuroscience, 2022 - frontiersin.org
Therapeutic interventions for disorders of fear and anxiety rely on behavioral approaches
that reduce pathological fear memories. For example, learning that threat-predictive stimuli …

Building and burying fear memories in the brain

S Maren - The Neuroscientist, 2005 - journals.sagepub.com
The world is a dangerous place. Whether this danger takes the form of an automobile
careening toward you or a verbal threat from a stranger, your brain is highly adapted to …

The surprising subtleties of changing fear memory: a challenge for translational science

M Kindt - Philosophical Transactions of the Royal Society …, 2018 - royalsocietypublishing.org
Current pharmacological and psychological treatments for disorders of emotional memory
only dampen the affective response while leaving the original fear memory intact. Under …

Extinction-reconsolidation boundaries: key to persistent attenuation of fear memories

MH Monfils, KK Cowansage, E Klann, JE LeDoux - science, 2009 - science.org
Dysregulation of the fear system is at the core of many psychiatric disorders. Much progress
has been made in uncovering the neural basis of fear learning through studies in which …

Neuronal circuits for fear expression and recovery: recent advances and potential therapeutic strategies

C Dejean, J Courtin, RR Rozeske, MC Bonnet… - Biological …, 2015 - Elsevier
Recent technological developments, such as single unit recordings coupled to optogenetic
approaches, have provided unprecedented knowledge about the precise neuronal circuits …