Learning to contend with threats in the environment is essential to survival, but dysregulation
of memories for traumatic events can lead to disabling psychopathology. Recent years have …

Post-traumatic stress disorder, panic disorder and phobia manifest in ways that are
consistent with an uncontrollable state of fear. Their development involves heredity, previous …

Over the course of natural history, countless animal species have evolved adaptive
behavioral systems to cope with dangerous situations and promote survival. Emotional …

Persistent anxiety after a psychological trauma is a hallmark of many anxiety disorders.
However, the neural circuits mediating the extinction of traumatic fear memories remain …

Current exposure-based therapies aimed to reduce pathological fear and anxiety are now
amongst the most effective interventions for trauma and anxiety related disorders …

Therapeutic interventions for disorders of fear and anxiety rely on behavioral approaches
that reduce pathological fear memories. For example, learning that threat-predictive stimuli …

The world is a dangerous place. Whether this danger takes the form of an automobile
careening toward you or a verbal threat from a stranger, your brain is highly adapted to …

Current pharmacological and psychological treatments for disorders of emotional memory
only dampen the affective response while leaving the original fear memory intact. Under …

Dysregulation of the fear system is at the core of many psychiatric disorders. Much progress
has been made in uncovering the neural basis of fear learning through studies in which …

Recent technological developments, such as single unit recordings coupled to optogenetic
approaches, have provided unprecedented knowledge about the precise neuronal circuits …