Dysregulated innate and adaptive immune responses discriminate disease severity in COVID-19
NAF Janssen, I Grondman… - The Journal of …, 2021 - academic.oup.com
The clinical spectrum of COVID-19 varies and the differences in host response
characterizing this variation have not been fully elucidated. COVID-19 disease severity …
characterizing this variation have not been fully elucidated. COVID-19 disease severity …
[HTML][HTML] The COVID-19 immune landscape is dynamically and reversibly correlated with disease severity
BACKGROUND Despite a rapidly growing body of literature on coronavirus disease 2019
(COVID-19), our understanding of the immune correlates of disease severity, course, and …
(COVID-19), our understanding of the immune correlates of disease severity, course, and …
[HTML][HTML] The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome
M Blot, JB Bour, JP Quenot, A Bourredjem… - Journal of translational …, 2020 - Springer
Background Although immune modulation is a promising therapeutic avenue in coronavirus
disease 2019 (COVID-19), the most relevant targets remain to be found. COVID-19 has …
disease 2019 (COVID-19), the most relevant targets remain to be found. COVID-19 has …
[HTML][HTML] Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients
The IMPACC cohort, composed of> 1,000 hospitalized COVID-19 participants, contains five
illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1 …
illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1 …
[PDF][PDF] Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia
Immune profiling of COVID-19 patients has identified numerous alterations in both innate
and adaptive immunity. However, whether those changes are specific to SARS-CoV-2 or …
and adaptive immunity. However, whether those changes are specific to SARS-CoV-2 or …
[HTML][HTML] Characterisation of the pro-inflammatory cytokine signature in severe COVID-19
Clinical outcomes from infection with SARS-CoV-2, the cause of the COVID-19 pandemic,
are remarkably variable ranging from asymptomatic infection to severe pneumonia and …
are remarkably variable ranging from asymptomatic infection to severe pneumonia and …
[PDF][PDF] Integrated immune dynamics define correlates of COVID-19 severity and antibody responses
SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which
remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or …
remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or …
Comprehensive mapping of immune perturbations associated with severe COVID-19
L Kuri-Cervantes, MB Pampena, W Meng… - Science …, 2020 - science.org
Although critical illness has been associated with SARS-CoV-2–induced hyperinflammation,
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …
[HTML][HTML] Dysregulated immune responses in SARS-CoV-2-infected patients: a comprehensive overview
I Kudryavtsev, A Rubinstein, A Golovkin, O Kalinina… - Viruses, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in
humans more than two years ago and caused an unprecedented socio-economic burden on …
humans more than two years ago and caused an unprecedented socio-economic burden on …
[HTML][HTML] Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions
COVID-19 has become a global pandemic. Immune dysregulation has been implicated, but
immune responses remain poorly understood. We analyzed 71 COVID-19 patients …
immune responses remain poorly understood. We analyzed 71 COVID-19 patients …