Targeted genome editing using engineered nucleases has rapidly gone from being a niche
technology to a mainstream method used by many biological researchers. This widespread …

Targeted genome editing using engineered nucleases has rapidly transformed from a niche
technology to a mainstream method used by many biological researchers. This widespread …

The development of clustered regularly interspaced short-palindromic repeat (CRISPR)-Cas
systems for genome editing has transformed the way life science research is conducted and …

The discovery and subsequent repurposing of the CRISPR (clustered regularly interspaced
short palindromic repeats) and Cas proteins (CRISPR-associated proteins) has …

Clustered regularly interspaced short palindromic repeats (CRISPR)-mediated manipulation
of genomic information is becoming more versatile by combining nuclease-deficient …

The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of
advances in the life sciences that have grown from the ability to edit genomes within living …

Compact and versatile CRISPR-Cas systems will enable genome engineering applications
through high-efficiency delivery in a wide variety of contexts. Here, we create an efficient …

CRISPR-Cas constitutes the adaptive immune system of bacteria and archaea. This RNA-
mediated sequence-specific recognition and targeting machinery has been used broadly for …

The prokaryote-derived CRISPR–Cas genome editing systems have transformed our ability
to manipulate, detect, image and annotate specific DNA and RNA sequences in living cells …

Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
(Cas) protein 9 system provides a robust and multiplexable genome editing tool, enabling …