Cellular senescence is a stress response that elicits a permanent cell cycle arrest and
triggers profound phenotypic changes such as the production of a bioactive secretome …

Senescent cells (SCs) accumulate with age and cause various age-related diseases.
Clearance of SCs by transgenic or pharmaceutical strategies has been demonstrated to …

Cellular senescence, once thought an artifact of in vitro culture or passive outcome of aging,
has emerged as fundamental to tissue development and function. The senescence …

Highlights•Cellular senescence is the biological central mechanism for the major age-
related diseases.•A large number of molecules, including synthetic senolytic and natural …

Cellular senescence has historically been viewed as an irreversible cell-cycle arrest
mechanism that acts to protect against cancer, but recent discoveries have extended its …

Strategies that can selectively eliminate senescent cells (SnCs), namely senolytics, have
been shown to promote healthy lifespan. However, it is challenging to achieve precise …

Send in the senolytics - Document - Gale OneFile: Health and Medicine Use this link to get
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