Decline in immune function and inflammation concomitantly develop with ageing. Here we
focus on the impact of this inflammatory environment on T cells, and demonstrate that in …

Changes to innate cells, such as macrophages and myeloid‐derived suppressor cells
(MDSC s), during aging in healthy or tumor‐bearing hosts are not well understood. We …

Aging results in profound immune dysfunction, resulting in the decline of vaccine
responsiveness previously attributed to irreversible defects in the immune system. In …

Aging leads to reduced immunity, especially adaptive responses. A key deficiency is the
poor ability to mount robust antibody response. Although intrinsic alterations in B cells with …

The role of macrophages and their interactions with T cells during aging is not well
understood. We determined if activating elderly-derived macrophages could rescue age …

Previously, we reported that IL-10-producing mononuclear phagocytes increase in lungs of
aged mice, causing impaired innate cytokine expression. Since dendritic cells (DCs) …

CD4 T cells, and especially T follicular helper cells, are critical for the generation of a robust
humoral response to an infection or vaccination. Importantly, immunosenescence affects …

Aging is associated with a gradual loss of naïve T cells and a reciprocal increase in the
proportion of memory T cells. While reduced thymic output is important, age-dependent …

Immunosenescence influences many components of the immune system. Most importantly,
profound changes in T cell function are evident in older individuals. The impact of aging on …

We have used a T‐cell receptor transgenic mouse model to study the role of antigen in the
changes that occur as T cells age. We find that the characteristic shift in the CD4 population …