Loss of skeletal muscle mass occurs frequently in clinical settings in response to joint
immobilization and bed rest, and is induced by a combination of unloading and inactivity …

Decreased skeletal muscle contractile activity (disuse) or unloading leads to muscle mass
loss, also known as muscle atrophy. The balance between muscle protein synthesis (MPS) …

Disuse is a potent inducer of muscle atrophy, but the molecular mechanisms driving this loss
of muscle mass are highly debated. In particular, the extent to which disuse triggers …

Prolonged periods of skeletal muscle inactivity or mechanical unloading (bed rest, hindlimb
unloading, immobilization, spaceflight and reduced step) can result in a significant loss of …

Muscle wasting resulting wholly or in part from disuse represents a serious medical
complication that, when prolonged, can increase morbidity and mortality. Although much …

Situations such as the recovery from injury and illness can lead to enforced periods of
muscle disuse or unloading. Such circumstances lead to rapid skeletal muscle atrophy, loss …

Skeletal muscle adapts to a prolonged reduction in physical activity by decreasing muscle
fibre size and protein content. This physiological response is commonly termed disuse …

Muscular dystrophy is a group of more than 30 different clinical genetic disorders that are
characterized by progressive skeletal muscle wasting and degeneration. Primary deficiency …

Skeletal muscle fibers have a unique capacity to adjust their metabolism and phenotype in
response to alternations in mechanical loading. Indeed, chronic mechanical loading leads to …

The ever increasing burden of an aging population and pandemic of metabolic syndrome
worldwide demands further understanding of the modifiable risk factors in reducing disability …