The role of natural killer cells in autoimmune diseases

UC Kucuksezer, E Aktas Cetin, F Esen… - Frontiers in …, 2021 - frontiersin.org
Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

Natural killer cells in human autoimmunity

M Flodström-Tullberg, YT Bryceson, FD Shi… - Current opinion in …, 2009 - Elsevier
Natural killer (NK) cells are innate immune cells. Although NK cells are best characterized
for their ability to control tumors and infections, recent data have indicated that they also are …

Natural killer cells in human autoimmune diseases

N Schleinitz, F Vély, JR Harlé, E Vivier - Immunology, 2010 - Wiley Online Library
Natural killer (NK) cells have been implicated in tumour surveillance and in the early control
of several microbial infections. In autoimmune disease their involvement in these processes …

NK cells in autoimmunity: a two-edg'd weapon of the immune system

R Perricone, C Perricone, C De Carolis… - Autoimmunity reviews, 2008 - Elsevier
Natural killer (NK) cells are part of the innate-immune system and respond rapidly to a
variety of insults via cytokine secretion and cytolytic activity. Their main function is first line of …

NK cell autoreactivity and autoimmune diseases

A Poggi, MR Zocchi - Frontiers in immunology, 2014 - frontiersin.org
Increasing evidences have pointed out the relevance of natural killer (NK) cells in organ-
specific and systemic autoimmune diseases. NK cells bear a plethora of activating and …

Natural killer cells: potential biomarkers and therapeutic target in autoimmune diseases?

E Gianchecchi, DV Delfino, A Fierabracci - Frontiers in immunology, 2021 - frontiersin.org
Autoimmune diseases recognize a multifactorial pathogenesis, although the exact
mechanism responsible for their onset remains to be fully elucidated. Over the past few …

Emerging role for NK cells in the pathogenesis of inflammatory arthropathies

P Conigliaro, R Scrivo, G Valesini, R Perricone - Autoimmunity reviews, 2011 - Elsevier
Natural killer (NK) cells are large, granular lymphocytes devoted to the defense against
microbial agents and cancer cells, traditionally recognized as an important arm of the innate …

NK cells: elusive players in autoimmunity

S Johansson, L Berg, H Hall, P Höglund - Trends in immunology, 2005 - cell.com
Natural killer (NK) cells were once regarded as relatively simple cells of the innate immune
system. However, they are now revealing themselves as multifunctional regulatory cells that …

Natural killer cells in inflammatory autoimmune diseases

Y Yang, J Day… - Clinical & …, 2021 - Wiley Online Library
Natural killer (NK) cells are a specialised population of innate lymphoid cells (ILCs) that help
control local immune responses. Through natural cytotoxicity, production of cytokines and …

The natural killer cell–friend or foe in autoimmune disease?

M Flodström, FD Shi, N Sarvetnick… - Scandinavian journal …, 2002 - Wiley Online Library
Autoimmune diseases are chronic conditions resulting from a loss of immunological
tolerance to self‐antigens. Recent observations have supported an ever‐broader role for …