TRK is a human transforming gene generated in a colon carcinoma by a somatic
rearrangement that fused a nonmuscle tropomyosin gene to sequences that shared …

The human trk oncogene (originally identified in a colon carcinoma) was activated by a
genetic rearrangement which resulted in replacement of the extracellular ligand-binding …

Molecular analysis of the human trk oncogene, a transforming gene isolated from a colon
carcinoma biopsy, revealed the existence of a novel member of the tyrosine kinase gene …

The human trk oncogene was generated by a genetic rearrangement that replaced the
extracellular domain of the normal trk tyrosine kinase receptor by sequences coding for the …

Transfection of NIH 3T3 cells with cDNA clones containing either the entire coding
sequences or the tyrosine protein kinase domain of the human TRK protooncogene results …

To date more than twenty five different oncogenes have been identified in human
neoplasias. One of these oncogenes is trk, a transforming gene originally isolated from a …

Monoclonal antibodies specific for the human trk protooncogene product, a tyrosine kinase
receptor, have been produced from mice in which tumors were generated by injection of …

Malignant activation of the human trk proto-oncogene, a member of the tyrosine protein
kinase receptor family, has been implicated in the development of certain human cancers …

The chromosomal localization of hTMnm, a gene coding for a cytoskeletal tropomyosin non-
muscle isoform involved in the activation of the TRK proto-oncogene in various human …

The trk oncogene was identified in gene transfer assays utilizing DNA isolated from a colon
carcinoma biopsy (Pulciani et al. 1982). Two human (Alu-posi-tive) EcoRI DNA fragments of …