[HTML][HTML] Impaired renal function and dysbiosis of gut microbiota contribute to increased trimethylamine-N-oxide in chronic kidney disease patients

KY Xu, GH Xia, JQ Lu, MX Chen, X Zhen, S Wang… - Scientific reports, 2017 - nature.com
Chronic kidney disease (CKD) patients have an increased risk of cardiovascular diseases
(CVDs). The present study aimed to investigate the gut microbiota and blood trimethylamine …

Gut Microbiota-Dependent Trimethylamine N-Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney …

WHW Tang, Z Wang, DJ Kennedy, Y Wu… - Circulation …, 2015 - Am Heart Assoc
Rationale: Trimethylamine-N-oxide (TMAO), a gut microbial-dependent metabolite of dietary
choline, phosphatidylcholine (lecithin), and l-carnitine, is elevated in chronic kidney …

[HTML][HTML] Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice

W Zhang, A Miikeda, J Zuckerman, X Jia… - Scientific reports, 2021 - nature.com
Patients with chronic kidney disease (CKD) have elevated circulating levels of
trimethylamine N-oxide (TMAO), a metabolite derived from gut microbes and associated with …

[HTML][HTML] Elevation of trimethylamine-N-oxide in chronic kidney disease: contribution of decreased glomerular filtration rate

CC Pelletier, M Croyal, L Ene, A Aguesse… - Toxins, 2019 - mdpi.com
Gut microbiota-dependent Trimethylamine-N-oxide (TMAO) has been reported to be strongly
linked to renal function and to increased cardiovascular events in the general population …

[HTML][HTML] Gut microbiota-derived trimethylamine N-oxide and kidney function: a systematic review and meta-analysis

Y Zeng, M Guo, X Fang, F Teng, X Tan, X Li, M Wang… - Advances in …, 2021 - Elsevier
Elevated circulating trimethylamine N-oxide (TMAO) concentrations have been observed in
patients with chronic kidney disease (CKD). We aimed to systematically estimate and …

[HTML][HTML] Trimethylamine N-oxide exacerbates renal inflammation and fibrosis in rats with diabetic kidney disease

Q Fang, B Zheng, N Liu, J Liu, W Liu, X Huang… - Frontiers in …, 2021 - frontiersin.org
The gut microbiota plays a pivotal role in the onset and development of diabetes and its
complications. Trimethylamine N-oxide (TMAO), a gut microbiota-dependent metabolite of …

Gut microbial metabolite TMAO increases peritoneal inflammation and peritonitis risk in peritoneal dialysis patients

L Zhang, F Xie, H Tang, X Zhang, J Hu, X Zhong… - Translational …, 2022 - Elsevier
Trimethylamine-N-oxide (TMAO), a gut microbiota-produced metabolite, is accumulated in
chronic kidney disease (CKD) patients. It is well known to contribute to CKD-related …

Targeted inhibition of gut microbial trimethylamine N-oxide production reduces renal tubulointerstitial fibrosis and functional impairment in a murine model of chronic …

N Gupta, JA Buffa, AB Roberts, N Sangwan… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: Gut microbial metabolism of dietary choline, a nutrient abundant in a Western diet,
produces trimethylamine (TMA) and the atherothrombosis-and fibrosis-promoting metabolite …

[HTML][HTML] TMAO as a potential biomarker and therapeutic target for chronic kidney disease: A review

Y Zixin, C Lulu, Z Xiangchang, F Qing… - Frontiers in …, 2022 - frontiersin.org
The gut microbiota and its metabolites have become a hotspot of recent research.
Trimethylamine N-oxide (TMAO) metabolized by the gut microbiota is closely related to …

[HTML][HTML] Gut Microbiota-Dependent Trimethylamine-N-oxide and Serum Biomarkers in Patients with T2DM and Advanced CKD

MAI Al-Obaide, R Singh, P Datta… - Journal of clinical …, 2017 - mdpi.com
Trimethylamine-N-oxide (TMAO) is a product of dietary, gut microbiome, and tissues
metabolism. Elevated blood TMAO levels are associated with heart attack, stroke and …