A scalable platform to identify fungal secondary metabolites and their gene clusters
KD Clevenger, JW Bok, R Ye, GP Miley… - Nature chemical …, 2017 - nature.com
The genomes of filamentous fungi contain up to 90 biosynthetic gene clusters (BGCs)
encoding diverse secondary metabolites—an enormous reservoir of untapped chemical …
encoding diverse secondary metabolites—an enormous reservoir of untapped chemical …
Correlative metabologenomics of 110 fungi reveals metabolite–gene cluster pairs
Natural products research increasingly applies-omics technologies to guide molecular
discovery. While the combined analysis of genomic and metabolomic datasets has proved …
discovery. While the combined analysis of genomic and metabolomic datasets has proved …
In the fungus where it happens: history and future propelling Aspergillus nidulans as the archetype of natural products research
In 1990 the first fungal secondary metabolite biosynthetic gene was cloned in Aspergillus
nidulans. Thirty years later,> 30 biosynthetic gene clusters (BGCs) have been linked to …
nidulans. Thirty years later,> 30 biosynthetic gene clusters (BGCs) have been linked to …
Microevolution in the pansecondary metabolome of Aspergillus flavus and its potential macroevolutionary implications for filamentous fungi
Fungi produce a wealth of pharmacologically bioactive secondary metabolites (SMs) from
biosynthetic gene clusters (BGCs). It is common practice for drug discovery efforts to treat …
biosynthetic gene clusters (BGCs). It is common practice for drug discovery efforts to treat …
An interpreted atlas of biosynthetic gene clusters from 1,000 fungal genomes
Fungi are prolific producers of natural products, compounds which have had a large societal
impact as pharmaceuticals, mycotoxins, and agrochemicals. Despite the availability of over …
impact as pharmaceuticals, mycotoxins, and agrochemicals. Despite the availability of over …
Accurate prediction of secondary metabolite gene clusters in filamentous fungi
MR Andersen, JB Nielsen, A Klitgaard… - Proceedings of the …, 2013 - National Acad Sciences
Biosynthetic pathways of secondary metabolites from fungi are currently subject to an
intense effort to elucidate the genetic basis for these compounds due to their large potential …
intense effort to elucidate the genetic basis for these compounds due to their large potential …
Fungal artificial chromosomes for mining of the fungal secondary metabolome
Background With thousands of fungal genomes being sequenced, each genome containing
up to 70 secondary metabolite (SM) clusters 30–80 kb in size, breakthrough techniques are …
up to 70 secondary metabolite (SM) clusters 30–80 kb in size, breakthrough techniques are …
Biosynthetic gene clusters and the evolution of fungal chemodiversity
Covering: up to 2019 Fungi produce a remarkable diversity of secondary metabolites: small,
bioactive molecules not required for growth but which are essential to their ecological …
bioactive molecules not required for growth but which are essential to their ecological …
Comprehensive curation and analysis of fungal biosynthetic gene clusters of published natural products
YF Li, KJS Tsai, CJB Harvey, JJ Li, BE Ary… - Fungal Genetics and …, 2016 - Elsevier
Microorganisms produce a wide range of natural products (NPs) with clinically and
agriculturally relevant biological activities. In bacteria and fungi, genes encoding successive …
agriculturally relevant biological activities. In bacteria and fungi, genes encoding successive …
Comprehensive annotation of secondary metabolite biosynthetic genes and gene clusters of Aspergillus nidulans, A. fumigatus, A. niger and A. oryzae
DO Inglis, J Binkley, MS Skrzypek, MB Arnaud… - BMC microbiology, 2013 - Springer
Background Secondary metabolite production, a hallmark of filamentous fungi, is an
expanding area of research for the Aspergilli. These compounds are potent chemicals …
expanding area of research for the Aspergilli. These compounds are potent chemicals …