Toxic effects and chemoresistance are major hurdles in chemotherapy and to avoid these
problems caused by traditional chemotherapeutic regimens, a new modality of drug …

The clinical efficacy and antiangiogenic effect of low-dose, metronomic administration of
cyclophosphamide (CTX) and methotrexate (MTX)(CM) have been demonstrated. The …

Most current chemotherapy regimens for cancer consist of empirically designed
combinations, based on efficacy and lack of overlapping toxicity. In the development of …

Therapeutic drug monitoring (TDM) is increasingly used in clinical practice for the
optimisation of drug treatment. Although pharmacokinetic variability is an established factor …

Metronomic dosed (MD) chemotherapy as opposed to conventional dosed (CD)
chemotherapy is considered an alternate strategy to target angiogenesis and limit host …

Purpose Metronomic chemotherapy has shown efficacy in patients with metastatic breast
cancer. When used in association with targeted antiangiogenic drugs, it was more active …

Drug resistance and toxic side effects are major therapeutic hurdles affecting cancer patients
receiving conventional chemotherapy based on the maximum tolerated dose. Metronomic …

In addition to proliferating cancer cells and various types of normal cells, such as those of
the bone marrow, conventional cytotoxic chemotherapeutics affect the endothelium of the …

Metronomic chemotherapy refers to the administration of chemotherapy at low, nontoxic
doses on a frequent schedule with no prolonged breaks. The aim of the study is to rationally …

A comment on this article appears in" Dose selection in phase I studies: why we should
always go for the most effective." J Clin Oncol. 2008 Jul 20; 26 (21): 3650-2; author reply …