ABSTRACT Mucin 1 (MUC1), a tumor-associated antigen, is a transmembrane glycoprotein
expressed by normal epithelial cells and overexpressed by carcinomas of epithelial origin …

Many obstacles still stand in the way to eliciting an effective immune response against
cancer, even though several antigens and antigenic peptides have been identified as …

There is still a great unmet medical need concerning diagnosis and treatment of breast
cancer which could be addressed by utilizing specific molecular targets. Tumor-associated …

The products of the MUC1 gene are known to be highly expressed in human breast cancer
cells. The best characterized MUC1 protein is a polymorphic, type 1 transmembrane …

The mucin MUC1 is typically aberrantly glycosylated by epithelial cancer cells manifested by
truncated O-linked saccharides. The resultant glycopeptide epitopes can bind cell surface …

Mucin-type O-glycans are found on mucins as well as many other glycoproteins. The
initiation step in synthesis is catalyzed by a large family of polypeptide GalNAc-transferases …

Mucin 1 (MUC1) contains N-and C-subunit that forms a heterodimer on the apical surface of
luminal epithelial cells. Nevertheless, MUC1 is aberrantly overexpressed in various cancers …

Mucins are large, heavily O‐glycosylated proteins expressed by epithelial tissues. The
canonical function of membrane mucins is to provide protection to vulnerable epithelia by …

MUC1 mucin is expressed by normal and malignant epithelial cells and is thought to
function through cell-cell interactions and transmembrane signal transduction events …

Chronic inflammation is a highly prevalent consequence of changes in environmental and
lifestyle factors that contribute to the development of cancer. The basis for this critical …