Human leukocyte antigen (HLA) class I proteins play a crucial role in the presentation of viral
peptide antigens to cytotoxic T cells during viral infection, which is necessary for mounting …

Objective: Human leucocyte antigen (HLA) class I alleles are the main host genetic factors
involved in controlling HIV-1 viral load (VL). Nevertheless, HLA diversity has proven a …

Abstract Human Leucocyte Antigen (HLA) class I alleles are the main host genetic factors
involved in controlling HIV-1 viral load (VL). Nevertheless, HLA diversity has proven a …

Background: Human leukocyte allele (HLA) class I polymorphism has the greatest impact of
human genetic variation on viral load set point. A substantial part of this effect is due to the …

Abstract Currently, 1.1 million individuals in the United States are living with HIV-1 infection.
Although this is a relatively small proportion of the global pandemic, the remarkable mix of …

Genetic variation in the peptide-binding groove of the highly polymorphic HLA class I
molecules has repeatedly been associated with HIV-1 control and progression to AIDS …

Heterozygosity of Human leukocyte antigen (HLA) class I genes is linked to beneficial
outcomes after HIV infection, presumably through greater breadth of HIV epitope …

Research in the past two decades has generated unequivocal evidence that host genetic
variations substantially account for the heterogeneous outcomes following human …

The human leukocyte antigen (HLA) gene loci are key in human immunodeficiency virus
(HIV) antigen presentation leading to an immune response to infection. The high genetic …

Polymorphic products of HLA class I genes restrict cytotoxic T lymphocyte responses to the
constantly evolving spectrum of HIV-1 antigens. Accordingly, homozygosity at class I loci can …