The retinoblastoma gene product is an abundant nuclear protein whose 'pocket
domain'mediates numerous protein–protein interactions. A substantial proportion of the RB …

The retinoblastoma protein (RB) plays a key role in the control of cell proliferation and
mediates the terminal differentiation of certain cell types. Increasing evidence suggests that …

The retinoblastoma protein, Rb, is encoded by a classic tumor suppressor gene that is
mutated in a large variety of tumors. Extensive studies have suggested that Rb functions as …

The human retinoblastoma (RB) gene product was first identified by antibodies raised
against a TrypE-human retinoblastoma (Rb) fusion protein expressed in E. coli. 1 These …

The identification of the retinoblastoma gene (rb) has sparked intense inves tigation of tumor
suppressor genes. These genes, like oncogenes, can encode transcriptional regulators …

Early studies of the retinoblastoma gene (RB) have uncovered its critical role as a regulator
of the G 1/S cell cycle phase progression. Surprisingly, genetic approaches in mammals and …

The product of the retinoblastoma gene (RB1) is believed to function as a negative regulator
of cell growth. Recent experimental results suggest that RB1 may exert its growth …

The retinoblastoma protein (Rb) is a tumor suppressor that regulates progression from the
G1 phase to the S phase of the cell cycle. Previously, we found that Rb is a transcriptional …

In cancer cells, the retinoblastoma tumor suppressor RB is directly inactivated by mutation in
the RB gene or functionally inhibited by abnormal activation of cyclin-dependent kinase …

Rb was the first tumour suppressor identified through human genetic studies. The most
significant achievement after almost twenty years since its cloning is the revelation that Rb …