C. difficile Microbiome Manipulation

J Penney, J Wick, T Basein, S Doron - Infection Prevention: New …, 2022 - Springer
Clostridioides difficile infection (CDI) is a healthcare-associated infection with significant
mortality, morbidity, and cost. Despite efforts by healthcare providers to adhere to infection …

Future Microbiome Therapeutics for Clostridioides difficile Infection

M Fischer, A Ray - Official journal of the American College of …, 2024 - journals.lww.com
In recent years, the increasing incidence of Clostridioides difficile infection (CDI) has posed
significant challenges to the medical community. The use of fecal microbiota transplants …

[HTML][HTML] How to: prophylactic interventions for prevention of Clostridioides difficile infection

E Reigadas, J van Prehn, M Falcone… - Clinical Microbiology …, 2021 - Elsevier
Background Clostridioides difficile infection (CDI) remains the leading cause of healthcare-
associated diarrhoea, despite existing guidelines for infection control measures and …

[HTML][HTML] Microbiota-Based Therapeutics as New Standard-of-Care Treatment for Recurrent Clostridioides difficile Infection

J Stallhofer, A Steube, K Katzer, A Stallmach - Visceral Medicine, 2024 - karger.com
Background: Clostridioides difficile (C. difficile) is a spore-forming bacterial species that
ubiquitously exists in the environment. Colonization by C. difficile is highly prevalent in …

Fulminant Clostridioides difficile infection: a review of treatment options for a life-threatening infection

TJ Carlson, AJ Gonzales-Luna… - Seminars in Respiratory …, 2022 - thieme-connect.com
Fulminant Clostridioides difficile infection (FCDI) encompasses 3 to 5% of all CDI cases with
associated mortality rates between 30 and 40%. Major treatment modalities include surgery …

[HTML][HTML] Updates and Opinions in Diagnosis and Treatment of Clostridiodes difficile in Pediatrics

S Malhotra, S Mohandas - Current Treatment Options in Pediatrics, 2021 - Springer
Purpose of review Clostridiodes difficile infection (CDI) has unique challenges for diagnosis
and treatment in pediatrics. Though new antibiotics and biologics are being approved or …

Recurrent Clostridioides difficile Infection: Current Clinical Management and Microbiome-Based Therapies

P Berry, S Khanna - BioDrugs, 2023 - Springer
Clostridioides difficile is one of the most important causes of healthcare-associated diarrhea.
The high incidence and recurrence rates of C. difficile infection, as well as its associated …

Clostridioides difficile infection: curbing a difficult menace

S Khanna, R Pardi - Therapeutic Advances in …, 2022 - journals.sagepub.com
Gastroenterology Volume 15 outline bile acids as a key metabolite of the gut microbiome
and review the association of changes between bile acid composition and CDI. Alterations …

[PDF][PDF] Clostridioides difficile Infection: A Clinical Review of Pathogenesis, Clinical Considerations, and Treatment Strategies

ES Sinnathamby, JW Mason, CJ Flanagan, NZ Pearl… - Cureus, 2023 - cureus.com
Background: Clostridioides difficile infection (CDI) is a common nosocomial infection. Risk
factors for developing CDI include prior hospitalization, being older than 65 years old …

Comparison of fidaxomicin to oral vancomycin for the treatment of Clostridioides difficile infection in hospitalized patients

AK Rao, Q Zhao, J Krishnan, J Bell, O Henig… - Antimicrobial …, 2022 - cambridge.org
Background: Clostridioides difficile infection (CDI) is a major source of morbidity and
mortality. Even after recovery, recurrent CDI (rCDI) occurs frequently, and concomitant …