The influence of genetic factors in schizophrenia has been convincingly demonstrated by
family, twin and adoption studies1–3, but the mode of transmission remains uncertain. The …

Genetic analysis is currently offering glimpses into molecular mechanisms underlying such
neuropsychiatric disorders as schizophrenia, bipolar disorder and autism. After years of …

People with schizophrenia are enriched for rare coding variants in genes associated with
neurodevelopmental disorders, particularly autism spectrum disorders and intellectual …

We carried out a genome-wide association study of schizophrenia (479 cases, 2,937
controls) and tested loci with P< 10− 5 in up to 16,726 additional subjects. Of 12 loci …

Genomic studies have identified hundreds of candidate genes near loci associated with risk
for schizophrenia. To define candidates and their functions, we mutated zebrafish orthologs …

This review critically summarizes the neuropathology and genetics of schizophrenia, the
relationship between them, and speculates on their functional convergence. The …

DNA methylation (DNAm) is important in brain development and is potentially important in
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …

The work conducted using genome-wide approaches during the past several years has
invigorated the field, and represents the dawn of molecular genetics of schizophrenia. The …

Schizophrenia is a condition that impairs higher brain functions, some of which are specific
to humans. After identification of susceptibility genes for schizophrenia, many efforts have …

Schizophrenia, a devastating psychiatric disorder, has a prevalence of 0.5–1%, with high
heritability (80–85%) and complex transmission. Recent studies implicate rare, large, high …