Objectives: Schizophrenia is a severe psychiatric disease affecting about 1% of the general
population. The relative contribution of genetic factors has been estimated to be up to 80 …

In order to help prioritize the selection of candidate genes and to study possible trait and not
state related changes in gene expression, we compared lymphocytic gene expression …

Schizophrenia is a debilitating mental illness that affects 1% of the population. Despite
intensive study, its molecular etiology remains enigmatic. Like many common diseases …

The history of psychiatric research on genotypes, phenotypes, and the brain reveals much
about the role of these concepts in our past and current understanding of schizophrenia and …

We interrogate the joint genetic architecture of 11 major psychiatric disorders at
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …

Large-scale gene expression studies in schizophrenia (SZ) have generally focused on the
dorsolateral prefrontal cortex. Despite a wealth of evidence implicating multiple other brain …

Background Why schizophrenia has accompanied humans throughout our history despite its
negative effect on fitness remains an evolutionary enigma. It is proposed that schizophrenia …

Despite the complexities of schizophrenia, notable progress has been achieved in its
diagnosis and treatment over the last 25 years. In this article we review the genetic research …

The complexity of the genetics of schizophrenia has been described by many investigators.
In the absence of simple Mendelian inheritance, genetic linkage has not achieved the …

Schizophrenia is a severe, complex mental disorder characterized by a combination of
positive symptoms, negative symptoms, and impaired cognitive function. Schizophrenia is …