Background Previous functional magnetic resonance imaging (fMRI) studies have shown
abnormal functional connectivity in regions involved in emotion processing and regulation in …

Pediatric bipolar disorder (PBD) is a severely debilitating illness, which is characterized by
episodes of mania and depression separated by periods of remission. Previous fMRI studies …

Background Early-onset bipolar disorder (BD) is a complex psychiatric illness characterized
by mood swings, irritability and functional impairments. To improve our understanding of the …

Objective Psychotic symptoms are quite common in patients with pediatric bipolar disorder
(PBD) and may affect the symptom severity and prognosis of PBD. However, the potential …

Background Bipolar disorder (BD) is a serious neuropsychiatric disorder characterized by
alternating periods of mania, depression, and euthymia. Abnormal spontaneous brain …

Bipolar disorder (BD) is a life-threatening illness which clinically defined by an alternating
pattern of depressive and manic episodes with a separated period of euthymia. It remains …

We examined resting state brain activity in the depressive phase of bipolar disorder (BD) by
measuring the amplitude of low-frequency fluctuations (ALFF) in the functional magnetic …

Objectives The spontaneous low frequency fluctuations (LFF) of blood oxygenation level-
dependent (BOLD) signal in resting state have been identified as a biological measure of …

BACKGROUND:: The recent upsurge in interest about pediatric bipolar disorder (BD) has
spurred the need for greater understanding of its neurobiology. Structural and functional …

Bipolar disorder may begin as depression or mania, which can affect the treatment and
prognosis of bipolar disorder. However, the physiological and pathological differences of …