Structural and functional insights into the spike protein mutations of emerging SARS-CoV-2 variants

D Gupta, P Sharma, M Singh, M Kumar… - Cellular and Molecular …, 2021 - Springer
Since the emergence of the first case of coronavirus disease 2019 (COVID-19), caused by
severe acute respiratory syndrome coronavirus (SARS-CoV-2), the viral genome has …

[HTML][HTML] Molecular insights into the adaptive evolution of SARS-CoV-2 spike protein

Z Yao, L Zhang, Y Duan, X Tang, J Lu - Journal of Infection, 2024 - Elsevier
The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), has substantially damaged the global economy and human health. The …

[HTML][HTML] Comprehensive structural and molecular comparison of spike proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and their interactions with ACE2

MM Hatmal, W Alshaer, MAI Al-Hatamleh, M Hatmal… - Cells, 2020 - mdpi.com
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has recently emerged
in China and caused a disease called coronavirus disease 2019 (COVID-19). The virus …

[HTML][HTML] The spike glycoprotein of SARS-CoV-2: A review of how mutations of spike glycoproteins have driven the emergence of variants with high transmissibility and …

PFN Souza, FP Mesquita, JL Amaral… - International journal of …, 2022 - Elsevier
Abstract Late in 2019, SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2)
emerged, causing an unknown type of pneumonia today called coronaviruses disease 2019 …

Molecular evolution of SARS-CoV-2 structural genes: Evidence of positive selection in spike glycoprotein

XY Zhan, Y Zhang, X Zhou, K Huang, Y Qian, Y Leng… - BioRxiv, 2020 - biorxiv.org
SARS-CoV-2 caused a global pandemic in early 2020 and has resulted in more than
8,000,000 infections as well as 430,000 deaths in the world so far. Four structural proteins …

Flexible, functional, and familiar: characteristics of SARS-CoV-2 spike protein evolution

DS Saputri, S Li, FJ Van Eerden, J Rozewicki… - Frontiers in …, 2020 - frontiersin.org
The SARS-CoV-2 S protein is a major point of interaction between the virus and the human
immune system. As a consequence, the S protein is not a static target but undergoes rapid …

Evolutionary and structural analysis elucidates mutations on SARS-CoV2 spike protein with altered human ACE2 binding affinity

S Chakraborty - Biochemical and biophysical research communications, 2021 - Elsevier
The recognition of ACE2 by the receptor-binding domain (RBD) of spike protein mediates
host cell entry. The objective of the work is to identify SARS-CoV2 spike variants that …

SARS-CoV-2 Virus− Host interaction: currently available structures and implications of variant emergence on infectivity and immune response

L Queirós-Reis, P Gomes da Silva, J Gonçalves… - International journal of …, 2021 - mdpi.com
Coronavirus disease 19, or COVID-19, is an infection associated with an unprecedented
worldwide pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 …

Molecular biology of the SARs‐CoV‐2 spike protein: A review of current knowledge

C Zhu, G He, Q Yin, L Zeng, X Ye… - Journal of medical …, 2021 - Wiley Online Library
The global coronavirus disease 2019 (COVID‐19) pandemic, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has led to an unprecedented worldwide …

Structure and mutations of SARS-CoV-2 spike protein: a focused overview

R Mehra, KP Kepp - ACS Infectious Diseases, 2021 - ACS Publications
The spike protein (S-protein) of SARS-CoV-2, the protein that enables the virus to infect
human cells, is the basis for many vaccines and a hotspot of concerning virus evolution …